Anti-VE-Cadherin Antibody (Rabbit Monoclonal antibody) General Information
Reacts with: Human
Recombinant Human VE-Cadherin / CD144 Protein
This antibody was obtained from a rabbit immunized with purified, recombinant Human VE-Cadherin / CD144 (CAA56306.1; Met1-Gln593).
Monoclonal Rabbit IgG Clone #012
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Immunochemical staining of human Cad5 in human stomach with rabbit monoclonal antibody (1:500, formalin-fixed paraffin embedded sections).
Immunochemical staining of human Cad5 in human kidney with rabbit monoclonal antibody (1:500, formalin-fixed paraffin embedded sections).
Anti-VE-Cadherin Antibody: Alternative Names
Anti-7B4 Antibody; Anti-CD144 Antibody
VE-Cadherin Background Information
Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.
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