Anti-VE-Cadherin Antibody

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Anti-VE-Cadherin Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-VE-Cadherin Antibody
Validated applications
IHC-P
Species reactivity
Reacts with: Human
Specificity
Human VE-Cadherin
Immunogen
Recombinant Human VE-Cadherin / CD144 Protein
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human VE-Cadherin / CD144 (CAA56306.1; Met1-Gln593).
Source
Monoclonal Rabbit IgG Clone #012
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-VE-Cadherin Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
IHC-P 1:250-1:1000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-VE-Cadherin Antibody (Rabbit Monoclonal antibody) Images

Immunochemical staining of human Cad5 in human stomach with rabbit monoclonal antibody (1:500, formalin-fixed paraffin embedded sections).
Immunochemical staining of human Cad5 in human kidney with rabbit monoclonal antibody (1:500, formalin-fixed paraffin embedded sections).

Anti-VE-Cadherin Antibody: Alternative Names

Anti-7B4 Antibody; Anti-CD144 Antibody

VE-Cadherin Background Information

Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.
Full Name
cadherin 5, type 2 (vascular endothelium)
References
  • Taveau JC, et al. (2008) Structure of artificial and natural VE-cadherin-based adherens junctions. Biochem Soc Trans. 36(Pt 2): 189-93.
  • Vestweber D. (2008) VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler Thromb Vasc Biol. 28(2): 223-32.
  • Gavard J. (2009) Breaking the VE-cadherin bonds. FEBS Lett. 583(1): 1-6.
  • Vestweber D, et al. (2009) Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player. Trends Cell Biol. 19(1): 8-15.
  • Boda-Heggemann J, et al. (2009) Beyond vessels: occurrence and regional clustering of vascular endothelial (VE-)cadherin-containing junctions in non-endothelial cells. Cell Tissue Res. 335(1): 49-65.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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