TRAIL: TRAIL Protein | TRAIL Antibody

TRAIL Gene family

TRAIL Background

Tumor necrosis factor ligand superfamily member 1 (TNFSF1), also known as TNF-related apoptosis-inducing ligand (TRAIL), Apo-2 ligand, and CD253, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF1 / Apo-2L / CD253 functions as a ligand that induces the process of cell death called apoptosis. TNFSF1 / TRAIL shows homology to other members of the tumor necrosis factor superfamily. As one member of the cluster of differentiation system, TNFSF1 / CD253 is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion TNFSF1 / Apo-2L / CD253 / TRAIL binds to several members of TNF receptor superfamily including TNFRSF1A / TRAILR1, TNFRSF1B / TRAILR2, TNFRSF1C / TRAILR3, TNFRSF1D / TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of TNFSF1 / TRAIL may be modulated by binding to the decoy receptors TNFRSF1C / TRAILR3, TNFRSF1D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8 / JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Reference for TRAIL

  • Song C, et al. (2005) TRAIL (CD253), a new member of the TNF superfamily. J Biol Regul Homeost Agents. 19(1-2): 73-7.
  • Kuribayashi K, et al. (2008) TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death. Cancer Biol Ther. 7(12): 2034-8.
  • Wiley SR, et al. (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity. 3(6): 673-82.

TRAIL Protein

TRAIL protein function

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. {ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:26457518}.

TRAIL protein expression

Tissue specificity

Widespread; most predominant in spleen, lung and prostate.

TRAIL protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    281.00
  • Mass (Da)
    32.00

TRAIL Antibody

There are 7 TRAIL antibodies which are validated in multiple tissues with various applications, including IHC-P, ICC/IF, ELISA, ELISA(Cap), WB. There are 2 TRAIL antibody for IHC-P, 1 TRAIL antibody for ICC/IF, 5 TRAIL antibody for ELISA, 1 TRAIL antibody for ELISA(Cap), 1 TRAIL antibody for WB. Among all these TRAIL antibodies, there are 5 anti-TRAIL rabbit polyclonal antibodies , 2 anti-TRAIL mouse monoclonal antibodies . All the TRAIL anbodies are produced in house and all are in stock. TRAIL antibody customerized service is available.

TRAIL Gene

TNFSF10 gene / cDNA is a protein-coding gene which located on 3q26. The TNFSF10 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.203 organisms have orthologs with human gene TNFSF10.