TNFRSF1B gene / cDNA is a protein-coding gene which located on 1p36.22. The TNFRSF1B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.167 organisms have orthologs with human gene TNFRSF1B.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
TNFR2 / TNFRSF1B cDNA / Gene Sequence
LOCUS NM_001066 3682 bp mRNA linear PRI 12-AUG-2018
Homo sapiens TNF receptor superfamily member 1B (TNFRSF1B), mRNA.
This sequence information is just for reference only.
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