TNFR2 / TNFRSF1B Matched ELISA Antibody Pair Set,Mouse

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TNFR2 / TNFRSF1B Matched ELISA Antibody Pair Set,Mouse General Information

Product name
TNFR2 / TNFRSF1B Matched ELISA Antibody Pair Set,Mouse
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Mouse TNFR2 / TNFRSF1B
Assay range
9.38-600 pg/mL
Materials provided
1. Capture Antibody 1.0 mg/mL of rabbit anti-mouse TNFRSF1B monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in CBS before coating. (Catalog: # 50128-R204)
2. Detection Antibody 0.5 mg/mL rabbit anti-mouse TNFRSF1B monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4). Dilute to working concentration of 0.5 μg/mL in detection antibody dilution buffer before use. (Catalog: # 50128-R340)
3. Standard Each vial contains 7 ng of recombinant mouse TNFRSF1B. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 0.6 ng/mL is recommended.
Product overview
This TNFR2 / TNFRSF1B Matched ELISA Antibody Pair Set,Mouse is a solid phase sandwich ELISA for quantitative determination of Mouse TNFR2 / TNFRSF1B . It contains Mouse TNFR2 / TNFRSF1B capture antibody, Mouse TNFR2 / TNFRSF1B detector antibody (HRP) and a highly purified HEK293-expressed recombinant Mouse TNFR2 / TNFRSF1B protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

TNFR2 / TNFRSF1B Matched ELISA Antibody Pair Set,Mouse Images

TNFR2 / TNFRSF1B Matched ELISA Antibody Pair Set,Mouse: Alternative Names

CD120b Matched ELISA Antibody Pair Set, Mouse; p75 Matched ELISA Antibody Pair Set, Mouse; TNF-alphaR2 Matched ELISA Antibody Pair Set, Mouse; TNF-R-II Matched ELISA Antibody Pair Set, Mouse; TNF-R2 Matched ELISA Antibody Pair Set, Mouse; TNF-R75 Matched ELISA Antibody Pair Set, Mouse; TNFalpha-R2 Matched ELISA Antibody Pair Set, Mouse; TNFBR Matched ELISA Antibody Pair Set, Mouse; Tnfr-1 Matched ELISA Antibody Pair Set, Mouse; Tnfr2 Matched ELISA Antibody Pair Set, Mouse; TNFR80 Matched ELISA Antibody Pair Set, Mouse; TNFRII Matched ELISA Antibody Pair Set, Mouse

TNFR2 / TNFRSF1B Background Information

Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD12b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD12b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD12b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD12b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Full Name
tumor necrosis factor receptor superfamily, member 1b
References
  • Komata T, et al. (1999) Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus. Tissue Antigens. 53(6): 527-33.
  • Tsuchiya N, et al. (2001) Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. Genes Immun. 2(6): 317-22.
  • Guo G, et al. (1999) Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy. Am J Physiol. 277(5): 766-72.
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