SETD7 (Protein | Antibody | cDNA Clone | ELISA Kit)

All SETD7 reagents are produced in house and quality controlled, including 5 SETD7 Antibody, 16 SETD7 Gene, 1 SETD7 IP Kit, 1 SETD7 Protein, 1 SETD7 qPCR. All SETD7 reagents are ready to use.

SETD7 Protein (1)

    SETD7 Antibody (5)

      SETD7 cDNA Clone (16)

      In expression vector

      SETD7 qPCR Primer (1)

      SETD7 Related Research Area

      SETD7 Background

      Histone-lysine N-methyltransferase SETD7, also known as SET domain containing (lysine methyltransferase) 7, SET7/9, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, and SETD7, is a member of thehistone-lysine methyltransferase family and SET7 subfamily. SETD7 is widely expressed and expressed in pancreatic islets. SETD7 contains three MORN repeats and one SET domain. SETD7 plays a central role in the transcriptional activation of genes such as collagenase or insulin. As a protein lysine methyltransferase (PKMT), SETD7 also has methyltransferase activity toward non-histone proteins such as p53/TP53, TAF1, and possibly TAF7 by recognizing and binding in substrate proteins. The mono-methyltransferase activity of SETD7 is achieved by disrupting the formation at near-attack conformations for the dimethylation reaction. SETD7 is also a novel coactivator of NF-kappaB and plays a role in inflammation and diabetes.

      SETD7 References

      • Wang, H. et al., 2002, Mol Cell 8 (6): 1207-17. 
      • Jacobs, SA. et al., 2002, Nat. Struct. Biol. 9 (11): 833-8. 
      • Xiao B, et al., 2003, Nature. 421 (6923): 652-6.
      • Martens, JH. et al., 2003, Mol. Cell. Biol. 23: 1808-1816.
      • Couture, JF. et al., 2006, Nat Struct Mol Biol  13 (2): 140-6.

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