PDGFRA Protein

PDGFRA Protein Overview

PDGFRA reagents

PDGFRA/FIP1L1 FUSION GENE, INCLUDED

PDGFRA protein family

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

PDGFRA protein name

Recommended name
Platelet-derived growth factor receptor alpha
Short name
PDGF-R-alpha||PDGFR-alpha
Aliases
CD140a, GAS9, PDGFR2
Alternative name
Alpha platelet-derived growth factor receptor Alpha-type platelet-derived growth factor receptor CD140 antigen-like family member A CD140a antigen Platelet-derived growth factor alpha receptor Platelet-derived growth factor receptor 2 CD_antigen: CD140a

PDGFRA Gene family protein

PDGFRA Protein Sequence

Species Human PDGFRA protein
Length 1089
Mass (Da) 122670
Sequence Human PDGFRA protein sequence
Species Mouse PDGFRA protein
Length 1089
Mass (Da) 122683
Sequence Mouse PDGFRA protein sequence
Species Rat PDGFRA protein
Length 1088
Mass (Da) 122642
Sequence Rat PDGFRA protein sequence

PDGFRA Protein Molecular Weight & PI

Platelet-derived growth factor receptor alpha precursor (EC 2.7.10.1) (PDGF-R-alpha) (PDGFR-alpha) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD140a antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 24-1089 Platelet-derived growth factor receptor

Molecular weight (Da)

120327.67

Theoretical pI

5.04

PDGFRA Protein Structure

Crystal structure of human PDGFRA
Deposited
2016-05-24   Released:  2016-08-17
Deposition Author(s)
Yan, X.E., Liang, L., Yun, C.H.
Organism(s)
Homo sapiens
Expression System
Spodoptera frugiperda
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.1680 Å
R-Value Free
0.224
R-Value Work
0.192
5K5X From PDB

Human PDGFRA protein Secondary structure

PDGFRA Protein Interaction

Recombinant PDGFRA Protein Feature

PDGFRA Protein, Human, Recombinant (His Tag)

High Purity
> 97 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measured by its ability to bind human PDGFC-Fc in functional ELISA.

Recombinant PDGFRA protein citations

Title
Development of a diagnostic assay for systemic sclerosis
Year
2013
Author
KN Pozniak
Journal
UNIVERSITÀ POLITECNICA DELLE MARCHE Facoltà di Medicina e Chirurgia
Title
Epitope specificity determines pathogenicity and detectability of anti-PDGFRα autoantibodies in systemic sclerosis
Year
2015
Author
Moroncini, G;Grieco, A;Nacci, G;Paolini, C;Tonnini, C;Pozniak, KN;Cuccioloni, M;Mozzicafreddo, M;Svegliati, S;Angeletti, M;Kazlauskas, A;Avvedimento, EV;Funaro, A;Gabrielli, A;
Journal
Arthritis & rheumatology
Title
Ultrastructural and Immunohistochemical Study on the Lamina Propria Cells Beneath Paneth Cells in the Rat Ileum
Year
2018
Author
Mantani, Y;Nishida, M;Yamamoto, K;Miyamoto, K;Yuasa, H;Masuda, N;Omotehara, T;Tsuruta, H;Yokoyama, T;Hoshi, N;Kitagawa, H;
Journal
Anat Rec (Hoboken)
Title
An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFRα Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma
Year
2018
Author
Yoon, S;Wu, X;Armstrong, B;Habib, N;Rossi, JJ;
Journal
Mol Ther Nucleic Acids

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