PD-L2 Protein

PD-L2 Protein Overview

PD-L2 reagents

By searching EST databases with mouse Pd1 ligand-1 (Pdl1, or B7H1; 605402), Latchman et al. (2001) identified cDNAs encoding mouse Pdl2 and human PDL2, which they cloned from a placenta cDNA library. Sequence analysis predicted that the 273-amino acid PDL2 protein, which is 70% identical to the mouse Pdl2 protein, contains a signal sequence, IgV- and IgC-like domains, a transmembrane region, and a cytoplasmic region. Northern blot analysis detected wide expression of PDL2, with highest levels in placenta, heart, pancreas, lung, and liver, and lower levels in spleen, lymph nodes, and thymus. Stimulation with gamma-interferon (IFNG; 147570) was required to detect expression in monocytes. By screening a subtractive dendritic cell (DC)-activated macrophage cDNA library, Tseng et al. (2001) isolated mouse and human cDNAs encoding PDL2, which they termed B7DC. Northern blot analysis detected Pdl2 transcripts in mouse DCs but not in primary macrophages or macrophage cell lines. Expression was also detected in human DCs but not in placenta.

PD-L2 protein family

Belongs to the immunoglobulin superfamily. BTN/MOG family.

PD-L2 protein name

Recommended name
Programmed cell death 1 ligand 2
Short name
PD-1 ligand 2||PD-L2||PDCD1 ligand 2||Program
Aliases
B7 dendritic cell molecule, B7-DC, bA574F11.2, Btdc, CD273, PDL2, PD-L2
Alternative name
Butyrophilin B7-DC CD_antigen: CD273

PD-L2 Gene family protein

PD-L2 Protein Sequence

Species Human PD-L2 protein
Length 273
Mass (Da) 30957
Sequence Human PD-L2 protein sequence
Species Mouse PD-L2 protein
Length 247
Mass (Da) 27820
Sequence Mouse PD-L2 protein sequence
Species
Length
Mass (Da)
Sequence

PD-L2 Protein Molecular Weight & PI

Programmed cell death 1 ligand 2 precursor (PD-1 ligand 2) (PD-L2) (PDCD1 ligand 2) (Programmed death ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 20-273 Programmed cell death 1 ligand 2.

Molecular weight (Da)

28777.13

Theoretical pI

8.49

PD-L2 Protein Interaction

Recombinant PD-L2 Protein Feature

PD-L2 Protein, Human, Recombinant (Fc Tag)

High Purity
> 95 % as determined by SDS-PAGE.
Low Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
High Activity
1. Measured by its binding ability in a functional ELISA. 2. Immobilized human PD1-His (Cat:10377-H08H) at 10 μg/mL (100 μL/well) can bind human PDCD1LG2-Fc. The EC50 of PDCD1LG2-Fc is 0.05-0.12 μg/mL.

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