IL4R: IL4R Protein | IL4R Antibody

IL4R Gene family

IL4R Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD124, also known as interleukin 4 receptor (IL4R), is a typeⅠ transmembrane protein that can regulate IgE antibody production in B cells through binding to interleukin 4 and interleukin 13 and promote differentiation of Th2 cells through binding to interleukin 4. The membrane-bound form of CD124 can be hydrolyzed to soluble form which can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells.

IL4R Protein

IL4R protein function

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. {ECO:0000269|PubMed:8124718}.; Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. {ECO:0000269|PubMed:8124718}.

IL4R protein expression

Tissue specificity

Isoform 1 and isoform 2 are highly expressed in activated T-cells.

IL4R protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

IL4R Antibody

There are 16 IL4R antibodies which are validated in multiple tissues with various applications, including ELISA, Neutralization, FCM. There are 9 IL4R antibody for ELISA, 2 IL4R antibody for Neutralization, 6 IL4R antibody for FCM. Among all these IL4R antibodies, there are 1 anti-IL4R mouse monoclonal antibodies , 10 anti-IL4R rabbit monoclonal antibodies , 5 anti-IL4R rabbit polyclonal antibodies . All the IL4R anbodies are produced in house and all are in stock. IL4R antibody customerized service is available.

IL4R Gene

IL4R gene / cDNA is a protein-coding gene which located on 16p12.1. The IL4R gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.195 organisms have orthologs with human gene IL4R.