IGF1R cDNA Clone: Expression and Clone Vector / Plasmid
IGF1R cDNA / Gene Overview
IGF1R gene / cDNA is a protein-coding gene which located on 15q26.3. The IGF1R gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.208 organisms have orthologs with human gene IGF1R.
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
IGF1R cDNA / Gene Sequence
LOCUS NM_000875 12262 bp mRNA linear PRI 05-AUG-2018
Homo sapiens insulin like growth factor 1 receptor (IGF1R), transcript variant 1, mRNA.
This sequence information is just for reference only.
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