IGF1R cDNA Clone: Expression and Clone Vector / Plasmid

IGF1R cDNA / Gene Overview

IGF1R gene / cDNA is a protein-coding gene which located on 15q26.3. The IGF1R gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.208 organisms have orthologs with human gene IGF1R.

IGF1R cDNA / Gene Function

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

IGF1R cDNA / Gene Sequence

LOCUS
LOCUS NM_000875 12262 bp mRNA linear PRI 05-AUG-2018
DEFINITION
Homo sapiens insulin like growth factor 1 receptor (IGF1R), transcript variant 1, mRNA.
ACCESSION
NM_000875 NM_015883
VERSION
NM_000875.4

This sequence information is just for reference only.

IGF1R Family & Reagents

IGF1R Gene family reagents (Receptor Tyrosine Kinases)

Approved Symbol Reagent list
MERTK
FGFR4
MET
ROR2
PDGFRA
FGFR1
KIT
Tie1
RYK
FLT1
Approved Symbol Reagent list
NTRK1
ROR1
CSF1R
DDR1
DDR2
INSR
FGFR2
KDR
FLT4
NTRK3

IGF1R Gene family reagents (CD molecules)

Approved Symbol Reagent list
MME
CD24
MS4A1
GP1BA
LAIR2
CDH2
TNFRSF13B
CD33
CSF3R
PROM1
Approved Symbol Reagent list
FZD4
IL10RB
FGFR3
CD37
CSF2RA
CD6
SLAMF1
IL1R1
TNFRSF18
SIGLEC5

IGF1R Gene family reagents (Fibronectin type III domain containing)

Approved Symbol Reagent list
GHR
LIFR
EphB1
CNTN4
EphA6
CDON
MERTK
EphB4
CNTN1
EphA3
Approved Symbol Reagent list
MPL
EphA4
IFNGR2
FLRT1
Tie1
FLRT2
CHL1
CNTFR
EPHA1
NCAM1

IGF1R cDNA / Gene Alias

  • CD221
  • IGFIR
  • IGFR
  • JTK13
  • MGC18216

IGF1R cDNA / Gene Expression

Ubiquitous expression in kidney (RPKM 8.9), ovary (RPKM 8.7) and 24 other tissues