The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
ATG12 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
autophagy-related protein 12 (ATG12) was a downstream protein that Ambra1 regulated EPI-induced autophagy. Therefore, Ambra1 plays an important role in regulating the sensitivity of breast cancer cells to EPI. And the regulatory effect of Ambra1 on EPI sensitivity is achieved through the regulation of autophagy by targeting ATG12. ATG12 is a novel targeting protein of Ambra1 in regulating EPI-induced autophagy. The important role of Ambra1 in modulating the sensitivity of breast cancer cells to EPI is confirmed in vivo. The autophagic ubiquitin-like protein (ublp) autophagy-related (ATG)12 is a component of the ATG12 approximately ATG5-ATG16L1 E3 complex that promotes lipid conjugation of members of the LC3 ublp family.
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