FGFR2 cDNA Clone: Expression and Clone Vector / Plasmid

FGFR2 cDNA / Gene Overview

FGFR2 gene / cDNA is a protein-coding gene which located on 10q26.13. The FGFR2 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog.217 organisms have orthologs with human gene FGFR2.

FGFR2 cDNA / Gene Function

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

FGFR2 cDNA / Gene Sequence

LOCUS
LOCUS NM_022976 1807 bp mRNA linear PRI 14-MAY-2006
DEFINITION
DEFINITION Homo sapiens fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) (FGFR2), transcript variant 9, mRNA.
ACCESSION
NM_022976
VERSION
NM_022976.1

This sequence information is just for reference only.

FGFR2 Family & Reagents

FGFR2 Gene family reagents (Receptor Tyrosine Kinases)

Approved Symbol Reagent list
MST1R
INSR
NTRK1
ROR2
DDR1
KIT
DDR2
FLT1
AXL
NTRK2
Approved Symbol Reagent list
RET
FGFR4
FGFR1
FLT3
MET
MUSK
KDR
PDGFRB
TEK
IGF1R

FGFR2 Gene family reagents (CD molecules)

Approved Symbol Reagent list
PTPRC
CEACAM8
GGT1
KIR2DL3
ICOSLG
KLRC1
CD69
KIR2DL1
TNFSF13B
MELTF
Approved Symbol Reagent list
FGFR3
IL6ST
ICAM1
LIFR
SIRPA
FASLG
TLR2
KLRK1
F3
NCR1

FGFR2 Gene family reagents (I-set domain containing)

Approved Symbol Reagent list
WFIKKN2
IL1RAPL1
LSAMP
NPTN
CEACAM5
SIGLEC6
ROR2
NTRK3
PDGFRA
MUSK
Approved Symbol Reagent list
FLT1
CNTN5
CLMP
FSTL5
OPCML
NEGR1
MAG
LRIG1
JAM2
LRRC4C

FGFR2 cDNA / Gene Alias

  • CD332
  • CEK3
  • Crouzon syndrome
  • ECT1
  • K-SAM
  • Pfeiffer syndrome
  • TK14
  • TK25

FGFR2 cDNA / Gene Expression

Broad expression in skin (RPKM 22.1), thyroid (RPKM 14.8) and 20 other tissues