Endoglin / CD105 cDNA Clone: Expression and Clone Vector / Plasmid

Endoglin / CD105 cDNA / Gene Overview

ENG gene / cDNA is a protein-coding gene which located on 9q34.11. The ENG gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and frog.180 organisms have orthologs with human gene ENG.

Endoglin / CD105 cDNA / Gene Function

This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]

Endoglin / CD105 cDNA / Gene Sequence

LOCUS
LOCUS NM_000118 3201 bp mRNA linear PRI 15-JUL-2018
DEFINITION
Homo sapiens endoglin (ENG), transcript variant 2, mRNA.
ACCESSION
NM_000118
VERSION
NM_000118.3

This sequence information is just for reference only.

Endoglin / CD105 Family & Reagents

Gene family

Endoglin / CD105 Gene family reagents (CD molecules)

Approved Symbol Reagent list
IL17RA
CRTAM
CDH5
IL9R
CD59
DDR1
CSF2RA
TNFRSF12A
CD1D
DPP4
Approved Symbol Reagent list
IL7R
NGFR
SELP
PTGFRN
FAS
ENPEP
F3
LY75
TNFSF13B
BTN3A1

Endoglin / CD105 cDNA / Gene Alias

  • CD105
  • END
  • HHT1

Endoglin / CD105 cDNA / Gene Expression

Broad expression in spleen (RPKM 69.2), lung (RPKM 66.7) and 24 other tissues