CDK9/CDC2L4: CDK9/CDC2L4 Protein | CDK9/CDC2L4 Antibody

CDK9/CDC2L4 Gene family

CDK9/CDC2L4 Protein

CDK9/CDC2L4 protein function

Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation.

CDK9/CDC2L4 protein expression

Tissue specificity

Ubiquitous.

Induction

By replication stress, in chromatin. Probably degraded by the proteasome upon Thr-186 dephosphorylation.

CDK9/CDC2L4 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    372.00
  • Mass (Da)
    42.00

CDK9/CDC2L4 Antibody

There are 1 CDK9/CDC2L4 antibodies which are validated in multiple tissues with various applications, including WB, IHC-P. There are 1 CDK9/CDC2L4 antibody for WB, 1 CDK9/CDC2L4 antibody for IHC-P. Among all these CDK9/CDC2L4 antibodies, there are 1 anti-CDK9/CDC2L4 rabbit polyclonal antibodies . All the CDK9/CDC2L4 anbodies are produced in house and all are in stock. CDK9/CDC2L4 antibody customerized service is available.

CDK9/CDC2L4 Gene

CDK9 cDNA / gene is a gene with protein product which located on 9q34.11. The CDK9 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, and frog. 241 organisms have orthologs with human gene CDK9.