CD89 Matched ELISA Antibody Pair Set,Human

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CD89 Matched ELISA Antibody Pair Set,Human General Information

Product name
CD89 Matched ELISA Antibody Pair Set,Human
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Human CD89
Assay range
7.81-500 pg/mL
Materials provided
1. Capture Antibody 0.5 mg/mL of rabbit anti-CD89 monoclonal antibody, Dilute to a working concentration of 2.0 μg/mL in CBS before coating. (Catalog: # 10414-R002)
2. Detection Antibody 0.25 mg/mL rabbit anti-CD89 polyclonal antibody conjugated to horseradish-peroxidase (HRP). Dilute to working concentration of 1.0 μg/mL in detection antibody dilution buffer before use.
3. Standard Each vial contains 30 ng of recombinant CD89. Reconstitute standard powder with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve usi ng 2-fold serial dilutions in sample dilution buffer, and a high standard of 500 pg/mL is recommended.
Product overview
This CD89 Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human CD89 . It contains Human CD89 capture antibody, Human CD89 detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human CD89 protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Protect it from prolonged exposure to light. Aliquot and store at -20℃ to -80℃ and for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

CD89 Matched ELISA Antibody Pair Set,Human Images

CD89 Matched ELISA Antibody Pair Set,Human: Alternative Names

CD89 Matched ELISA Antibody Pair Set, Human; CTB-61M7.2 Matched ELISA Antibody Pair Set, Human; FcalphaRI Matched ELISA Antibody Pair Set, Human; FCAR Matched ELISA Antibody Pair Set, Human; XXbac-BPG230H20.5 Matched ELISA Antibody Pair Set, Human

CD89 Background Information

FCAR, also called FcαRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.
Full Name
Fc fragment of IgA receptor
References
  • Maliszewski, C.R. et al., 1990, J. Exp. Med. 172: 1665-1672.
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