CD89: CD89 Protein | CD89 Antibody

CD89 Gene family

CD89 Background

FCAR, also called FcαRI or CD89, is a type I  transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.

Reference for CD89

  • Maliszewski, C.R. et al., 1990, J. Exp. Med. 172: 1665-1672.

CD89 Protein

CD89 protein function

Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. {ECO:0000269|PubMed:12768205}.

CD89 protein expression

Tissue specificity

Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.

CD89 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

CD89 Antibody

There are 11 CD89 antibodies which are validated in multiple tissues with various applications, including ELISA, FCM, ELISA(Cap). There are 7 CD89 antibody for ELISA, 4 CD89 antibody for FCM, 1 CD89 antibody for ELISA(Cap). Among all these CD89 antibodies, there are 4 anti-CD89 mouse monoclonal antibodies , 3 anti-CD89 rabbit monoclonal antibodies , 4 anti-CD89 rabbit polyclonal antibodies . All the CD89 anbodies are produced in house and all are in stock. CD89 antibody customerized service is available.

CD89 Gene

FCAR gene / cDNA is a protein-coding gene which located on 19q13.42. The FCAR gene is conserved in chimpanzee, Rhesus monkey, cow, and rat.51 organisms have orthologs with human gene FCAR.