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BAFFR/TNFRSF13C (Protein | Antibody | cDNA Clone | ELISA Kit)

All BAFFR/TNFRSF13C reagents are produced in house and quality controlled, including 1 BAFFR/TNFRSF13C Antibody, 39 BAFFR/TNFRSF13C Gene, 5 BAFFR/TNFRSF13C Lysate, 5 BAFFR/TNFRSF13C Protein, 2 BAFFR/TNFRSF13C qPCR. All BAFFR/TNFRSF13C reagents are ready to use.

BAFFR/TNFRSF13C Protein (5)

    BAFFR/TNFRSF13C Antibody (1)

      BAFFR/TNFRSF13C cDNA Clone (39)

      NM_052945.3
      NM_028075.2
      XM_576316.3

      BAFFR/TNFRSF13C Lysate (5)

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        BAFFR/TNFRSF13C Background

        Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. A tumor necrosis factor receptor (TNFR), or death receptor, is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). The receptor cooperates with an adaptor protein which is important in determining the outcome of the response. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors or tumour necrosis factor (TNFR), on their surface. Tumour necrosis factors (TNFR) detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery. It has been proposed that abnormally high levels of BAFFR/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

        BAFFR/TNFRSF13C References

        • Ashkenazi A, et al. (1998) Death receptors: signaling and modulation. Science. 281(5381): 1305-8.
        • Losi CG, et al. (2005) Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency. J Clin Immunol. 25(5): 496-502.
        • Hentges KE, et al. (2002) Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22. Genomics. 80(2): 204-12.

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