C1QB: C1QB Protein | C1QB Antibody

C1QB Gene family

C1QB Background

Complement Component 1, q subcomponent (C1q) associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Southern blot analysis of chromosomal DNA from vertebrate species demonstrated highest similarity between the C1qB genes, followed by C1qC and finally C1qA. Sequence comparison of C1q from three different species have shown that the B chains have the strongest similarity. C1q was already present at embryonic day 14 (E14) and showed little change in abundance through six weeks postnatal. At E16, C1qB mRNA was present at high abundance in putative microglia/macrophages in cortical marginal and intermediate zones, and hippocampal analge.

Reference for C1QB

  • Pasinetti GM, et al. (1992) Complement C1qB and C4 mRNAs responses to lesioning in rat brain. Experimental neurology. 118(2): 117-25.
  • Johnson SA, et al. (1994) Expression of complement C1qB and C4 mRNAs during rat brain development. Brain Res Dev Brain Res. 80(1-2): 163-74.
  • Grewal RP,et al. (1999) C1qB and clusterin mRNA increase in association with neurodegeneration in sporadic amyotrophic lateral sclerosis. Neuroscience letters. 271(1): 65-7.
  • Spielman L, et al. (2002) Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2. Acta neuropathologica. 103(2): 157-62.

C1QB Protein

C1QB protein function

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

C1QB protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    253.00
  • Mass (Da)
    26.00

C1QB Antibody

There are 1 C1QB antibodies which are validated in multiple tissues with various applications, including IHC-P. There are 1 C1QB antibody for IHC-P. Among all these C1QB antibodies, there are 1 anti-C1QB rabbit polyclonal antibodies . All the C1QB anbodies are produced in house and all are in stock. C1QB antibody customerized service is available.

C1QB Gene

C1QB gene / cDNA is a protein-coding gene which located on 1p36.12. The C1QB gene is conserved in chimpanzee, dog, cow, mouse, rat, and chicken.177 organisms have orthologs with human gene C1QB.