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Anti-LAG3 Antibody

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Anti-LAG3 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-LAG3 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse LAG3
Immunogen
Recombinant Mouse LAG3/LAG-3/CD223 Protein (Catalog#53069-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse LAG3/LAG-3/CD223 (rM LAG3/LAG-3/CD223; Catalog#53069-M08H; NP_032505.1; Met1-Leu442). LAG3/LAG-3/CD223 specific IgG was purified by Mouse LAG3/LAG-3/CD223 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
PBS, pH7.0 with 0.03% Proclin300
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Anti-LAG3 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-LAG3 Antibody: Alternative Names

Anti-CD223 Antibody; Anti-LAG-3 Antibody; Anti-Ly66 Antibody

LAG3 Background Information

LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells. It also acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signalling, leading to increased antigen-specific T-cell responses in vivo.
Full Name
lymphocyte-activation gene 3
References
  • Sigrid Hannier. et al., 1998, The Journal of Immunology. 161(8): 4058-65.
  • Triebel F. et al., 1990, J Exp Med. 171 (5): 1393-405.
  • Baixeras E. et al., 1992, J Exp Med. 176 (2): 327-37.
  • Huard B. et al., 1997, Proc Natl Acad Sci. 94 (11): 5744-9.
  • Kisielow M. et al., 2005, Eur J Immunol. 35 (7): 2081-8.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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