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Человек WSX-1/IL-27R Джин клон кДНК в вектор клонирования

ПаспортОбзорыСвязанные продуктыПротоколы
Human IL27RA Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_004843.2
Размер кДНК:1911bp
Описание кДНК:Full length Clone DNA of Homo sapiens interleukin 27 receptor, alpha.
Синоним гена:CRL1, TCCR, WSX1, IL27R, zcytor1, IL27RA
Виды:Human
переносчик:pGEM-T Vector
Plasmid:pGEM-IL27RA
Участок рестрикции:
Последовательность меток:
Описание последовательности:Identical with the Gene Bank Ref. ID sequence.
Sequencing primers:SP6 and T7 or M13-47 and RV-M
Promoter:
Application:
Antibiotic in E.coli:Ampicilin
Antibiotic in mammalian cell:
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
pGEM-T Vector Information

The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.

pGEM-T Simple Usage Suggestion:

The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.

Vector Sequence Download
Человек WSX-1/IL-27R Джин клон кДНК в вектор клонирования on other vectors
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаHG10489-ACGRBS16760
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаHG10489-ACRRBS16760
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаHG10489-CFRBS14710
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаHG10489-CHRBS14710
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаHG10489-CMRBS14710
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаHG10489-CYRBS14710
Человек WSX-1/IL-27R Джин клон кДНК в вектор клонированияHG10489-GRBS5130
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаHG10489-NFRBS14710
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаHG10489-NHRBS14710
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаHG10489-NMRBS14710
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаHG10489-NYRBS14710
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмидыHG10489-UTRBS14710
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Фон

The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit and glycoprotein 130. WSX-1/IL-27R, a class I cytokine receptor that is homologous to the β2 chain of the IL-12R in both sequence and structure, is highly expressed by resting/naive CD4+ T cells and CD8+ T cells. WSX-1/IL-27R belongs to the IL-6/IL-12 family of cytokines and induced proliferation of naive CD4(+) T cells and the generation of a Th1-type adaptive immune response. WSX-1/IL-27R functions as a receptor for IL27. IL-27 not only contributes to the development of an adaptive immune response through its action on CD4(+) T cells, it also directly acts on cells of the innate immune system. WSX-1/IL-27R requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. It is involved in the regulation of Th1-type immune responses. IL-27R also appears to be involved in innate defense mechanisms. IL27RA is essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation.

Ссылки
  • Pflanz S, et al.. (2004) WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J Immunol. 172(4): 2225-31.
  • Yoshida H, et al.. (2001) WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity. 215(4): 569-78.
  • Villarino A, et al.. (2003) The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity. 19(5): 645-55.
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    Каталог: HG10489-G
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