Anti-Thrombopoietin Antibody (Rabbit Monoclonal antibody) General Information
Reacts with: Mouse
Recombinant Mouse Thrombopoietin / THPO protein (Catalog#50146-M08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Thrombopoietin / THPO (rM Thrombopoietin / THPO; Catalog#50146-M08H; NP_033405.1; Met 1-Thr 356).
Monoclonal Rabbit IgG Clone #444
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Thrombopoietin (TPO or THPO), also known as myeloproliferative leukemia virus ligand (c-Mpl), is a hematopoietic growth factor belonging to the EPO/TPO family. The thrombopoietin protein is produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. Thrombopoietin protein stimulates both proliferation of progenitor megakaryocytes and their maturation to platelet-producing megakaryocytes, and also accelerates the recovery of platelets. Thrombopoietin protein is involved in cardiovascular disease as it regulates megakaryocyte development and enhances platelet adhesion/aggregation. It has been identified that surface c-MPL, the receptor for thrombopoietin protein, binds to the ligand and mediates the action.