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Человек Thioredoxin-2/TXN2 Джин клон кДНК в вектор клонирования

ПаспортОбзорыСвязанные продуктыПротоколы
Human TXN2 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:BC013726
Размер кДНК:501bp
Описание кДНК:Full length Clone DNA of Homo sapiens thioredoxin 2.
Синоним гена:MTRX, TRX2, MT-TRX
Виды:Human
переносчик:pGEM-T Vector
Plasmid:pGEM-TXN2
Участок рестрикции:
Последовательность меток:
Описание последовательности:Identical with the Gene Bank Ref. ID sequence.
Sequencing primers:SP6 and T7 or M13-47 and RV-M
Promoter:
Application:
Antibiotic in E.coli:Ampicilin
Antibiotic in mammalian cell:
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
pGEM-T Vector Information

The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.

pGEM-T Simple Usage Suggestion:

The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.

Vector Sequence Download
Человек Thioredoxin-2/TXN2 Джин клон кДНК в вектор клонирования on other vectors
Человек Thioredoxin-2/TXN2 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаHG12557-ACGRBS15400
Человек Thioredoxin-2/TXN2 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаHG12557-ACRRBS15400
Человек Thioredoxin-2/TXN2 Джин ORF экспрессии кДНК клона плазмиды, N-GFPSpark МеткаHG12557-ANGRBS15400
Человек Thioredoxin-2/TXN2 Джин ORF экспрессии кДНК клона плазмиды, N-OFPSpark МеткаHG12557-ANRRBS15400
Человек Thioredoxin-2/TXN2 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаHG12557-CFRBS13340
Человек Thioredoxin-2/TXN2 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаHG12557-CHRBS13340
Человек Thioredoxin-2/TXN2 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаHG12557-CMRBS13340
Человек Thioredoxin-2/TXN2 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаHG12557-CYRBS13340
Человек Thioredoxin-2/TXN2 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаHG12557-NFRBS13340
Человек Thioredoxin-2/TXN2 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаHG12557-NHRBS13340
Человек Thioredoxin-2/TXN2 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаHG12557-NMRBS13340
Человек Thioredoxin-2/TXN2 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаHG12557-NYRBS13340
Человек Thioredoxin-2/TXN2 Джин ORF экспрессии кДНК клона плазмидыHG12557-UTRBS13340
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Фон

Thioredoxin-2, also known as TXN2, MTRX and TRX2, is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which, as trypanothione:peroxiredoxin oxidoreductases, constitute the trypanothione-dependent antioxidant defense and may also serve as substrates for ribonucleotide reductase in trypanosomatids. Thioredoxin-2 / TXN2 contains one thioredoxin domain. It is widely expressed in adult (at protein level) and fetal tissues. Human Thioredoxin-2 / TXN2 is a small redox protein important in cellular antioxidant defenses, as well as in the regulation of apoptosis. Thioredoxin-2 / TXN2 has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Thioredoxin-2 / TXN2 could be involved in the resistance to anti-tumor agents. It possesses a dithiol-reducing activity. Thioredoxin-2 / TXN2 plays an important role in protecting the mitochondria against oxidative stress and in sensitizing the cells to ROS-induced apoptosis. Mammalian Thioredoxin-2 / TXN2 is a mitochondrial isoform of highly evolutionary conserved thioredoxins. Thioredoxins are small ubiquitous protein-disulfide oxidoreductases implicated in a large variety of biological functions.

Ссылки
  • Chen Y., et al., 2002, J. Biol. Chem. 277: 33242-8.
  • Smeets A., et al., 2005, Protein Sci. 14: 2610-21.
  • Wen,S. et al., 2009, Am J Med Genet A  149A (2): 155-60.
  • Choudhary C., et al., 2009, Science 325: 834-40.
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    Каталог: HG12557-G
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