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Мышь Osteoprotegerin/TNFRSF11B Джин клон кДНК в вектор клонирования

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Mouse TNFRSF11B Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_008764.3
Размер кДНК:1206bp
Описание кДНК:Full length Clone DNA of Mus musculus tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin).
Синоним гена:Opg, TR1, OCIF
Виды:Mouse
переносчик:pGEM-T Vector
Plasmid:pGEM-mTNFRSF11B
Участок рестрикции:
Последовательность меток:
Описание последовательности:Identical with the Gene Bank Ref. ID sequence.
Sequencing primers:SP6 and T7 or M13-47 and RV-M
Promoter:
Application:
Antibiotic in E.coli:Ampicilin
Antibiotic in mammalian cell:
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
pGEM-T Vector Information

The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.

pGEM-T Simple Usage Suggestion:

The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.

Vector Sequence Download
Мышь Osteoprotegerin/TNFRSF11B Джин клон кДНК в вектор клонирования on other vectors
Мышь Osteoprotegerin/TNFRSF11B Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаMG52613-ACGRBS15396
Мышь Osteoprotegerin/TNFRSF11B Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаMG52613-ACRRBS15396
Мышь Osteoprotegerin/TNFRSF11B Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаMG52613-CFRBS13343
Мышь Osteoprotegerin/TNFRSF11B Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаMG52613-CHRBS13343
Мышь Osteoprotegerin/TNFRSF11B Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаMG52613-CMRBS13343
Мышь Osteoprotegerin/TNFRSF11B Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаMG52613-CYRBS13343
Мышь Osteoprotegerin/TNFRSF11B Джин клон кДНК в вектор клонированияMG52613-GRBS5132
Мышь Osteoprotegerin/TNFRSF11B Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаMG52613-NFRBS13343
Мышь Osteoprotegerin/TNFRSF11B Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаMG52613-NHRBS13343
Мышь Osteoprotegerin/TNFRSF11B Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаMG52613-NMRBS13343
Мышь Osteoprotegerin/TNFRSF11B Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаMG52613-NYRBS13343
Мышь Osteoprotegerin/TNFRSF11B Джин ORF экспрессии кДНК клона плазмидыMG52613-UTRBS13343
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Фон

Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Osteoprotegerin/TNFRSF11B acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. This protein may inhibit the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. Osteoprotegerin/TNFRSF11B also play a role in preventing arterial calcification, act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.

Ссылки
  • Collin-Osdoby P. (2005) Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. Circ Res. 95 (11): 1046-57.
  • Boyce BF, et al. (2007) Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res. Ther. 9 Suppl 1: S1.
  • Blázquez-Medela AM, et al. ( 2011) Osteoprotegerin and diabetes-associated pathologies. Curr Mol Med. 11 (5): 401-16.
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    Каталог: MG52613-G
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