Anti-TNF-alpha Antibody

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Anti-TNF-alpha Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-TNF-alpha Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse TNF-alpha
Has cross-reactivity in ELISA with
Human TNFa
Immunogen
Recombinant Mouse TNF-alpha / TNFa protein (Catalog#50349-MNAE)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TNF-alpha / TNFa (rM TNF-alpha / TNFa; Catalog#50349-MNAE; NP_038721.1; Leu 80-Leu 235).
Source
Monoclonal Rabbit IgG Clone #009
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-TNF-alpha Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-TNF-alpha Antibody: Alternative Names

Anti-DIF Antibody; Anti-TNF-a Antibody; Anti-TNF-alpha Antibody; Anti-Tnfa Antibody; Anti-TNFalpha Antibody; Anti-Tnfsf1a Antibody; Anti-TNFSF2 Antibody

TNF-alpha Background Information

Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD12a; p55/6) and TNF-R2 (TNF receptor type 2; CD12b; p75/8), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.

TNF-alpha Protein & AntibodyImmune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy

Full Name
tumor necrosis factor
Research Areas
References
  • Hector J, et al. (2007) TNF-alpha alters visfatin and adiponectin levels in human fat. Horm Metab Res. 39(4): 250-5.
  • Berthold-Losleben M, et al. (2008) The TNF-alpha System: Functional Aspects in Depression, Narcolepsy and Psychopharmacology. Curr Neuropharmacol. 6(3): 193-202.
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