TGF beta 2 cDNA ORF Clone, Rat, N-Myc tag

Cat: RG80119-NM

Contact us:

215-583-7898
order@sinobiological.com
Distributors

All TGF beta 2 Reagents

CRO Services

Product recommended


All TGF beta 2 Reagents

TGF beta 2 cDNA ORF Clone, Rat, N-Myc tag General Information

Gene

Species
Rat
NCBI Ref Seq
RefSeq ORF Size
1245 bp
Description
Full length Clone DNA of Rat transforming growth factor, beta 2 with N terminal Myc tag.

Plasmid

Promoter
Enhanced CMV promoter
Tag Sequence
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.

Screening

Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression

Storage & Shipping

Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

TGF beta 2 Background Information

TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. TGF beta 2 suppression is a promising therapeutic approach for malignant tumor therapy. The signaling pathway of TGF beta 2/Smad plays an important role in the pathological process in posterior capsule opacification (PCO) after cataract surgery. Silencing Smad2 and Smad3 efficiently blocked the effect of TGF beta 2 on cell proliferation, migration, and extracellular matrix production. TGF beta 2 activation of MEKK3/ERK1/2/5 signaling modulates Has2 expression and hyaluronan (HA) production leading to the induction of epithelial to mesenchymal transformation (EMT) events. In addition, the upregulation of the TGF beta 2 level is a common pathological feature of Alzheimer's disease (AD) brains and suggests that it may be closely linked to the development of neuronal death related to AD.

Full Name
transforming growth factor beta 2
References
  • Schlingensiepen KH, et al. (2006) Targeted tumor therapy with the TGF-beta 2 antisense compound AP 12009. Cytokine Growth Factor Rev. 17(1-2): 129-39.
  • Ghatpande SK, et al. (2010) Transforming growth factor beta2 is negatively regulated by endogenous retinoic acid during early heart morphogenesis. Dev Growth Differ. 52(5): 433-55.
  • Noguchi A, et al. (2010) Transforming growth factor beta2 level is elevated in neurons of Alzheimer's disease brains. Int J Neurosci. 120(3): 168-75.
  • Li J, et al. (2011) Comparative effects of TGF-_2/Smad2 and TGF-_2/Smad3 signaling pathways on proliferation, migration, and extracellular matrix production in a human lens cell line. Exp Eye Res. 92(3): 173-9.
  • TGF beta 2 cDNA ORF Clone, Canine, Related Products

    Product Name Catalog#(PDF)
    TGF beta 2 cDNA ORF Clone in Cloning Vector, Canine DG70099-G

    TGF beta 2 cDNA ORF Clone, Rhesus, Related Products

    Product Name Catalog#(PDF)
    TGF beta 2 cDNA ORF Clone in Cloning Vector, Rhesus CG90036-G
    TGF beta 2 cDNA ORF Clone, Rhesus, untagged CG90036-UT
    TGF beta 2 cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90036-ACG
    TGF beta 2 Lentiviral cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90036-ACGLN
    TGF beta 2 cDNA ORF Clone, Rhesus, C-OFPSpark® tag CG90036-ACR
    TGF beta 2 cDNA ORF Clone, Rhesus, C-DDK (Flag®) tag CG90036-CF
    TGF beta 2 cDNA ORF Clone, Rhesus, N-DDK (Flag®) tag CG90036-NF
    TGF beta 2 cDNA ORF Clone, Rhesus, C-His tag CG90036-CH
    TGF beta 2 cDNA ORF Clone, Rhesus, N-His tag CG90036-NH
    TGF beta 2 cDNA ORF Clone, Rhesus, C-HA tag CG90036-CY
    TGF beta 2 cDNA ORF Clone, Rhesus, N-HA tag CG90036-NY
    TGF beta 2 cDNA ORF Clone, Rhesus, C-Myc tag CG90036-CM
    TGF beta 2 cDNA ORF Clone, Rhesus, N-Myc tag CG90036-NM

    TGF beta 2 cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    TGF beta 2 cDNA ORF Clone in Cloning Vector, Rat RG80119-G
    TGF beta 2 cDNA ORF Clone, Rat, untagged RG80119-UT
    TGF beta 2 Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG80119-ACGLN
    TGF beta 2 cDNA ORF Clone, Rat, C-GFPSpark® tag RG80119-ACG
    TGF beta 2 cDNA ORF Clone, Rat, C-OFPSpark® tag RG80119-ACR
    TGF beta 2 cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG80119-CF
    TGF beta 2 cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80119-NF
    TGF beta 2 cDNA ORF Clone, Rat, C-His tag RG80119-CH
    TGF beta 2 cDNA ORF Clone, Rat, N-His tag RG80119-NH
    TGF beta 2 cDNA ORF Clone, Rat, C-HA tag RG80119-CY
    TGF beta 2 cDNA ORF Clone, Rat, N-HA tag RG80119-NY
    TGF beta 2 cDNA ORF Clone, Rat, C-Myc tag RG80119-CM
    TGF beta 2 qPCR Primer Pairs, Rat RP300114

    TGF beta 2 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    TGF beta 2 cDNA ORF Clone in Cloning Vector, Mouse MG50153-M
    TGF beta 2 cDNA ORF Clone, Mouse, untagged MG50153-UT
    TGF beta 2 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50153-ACGLN
    TGF beta 2 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50153-ACG
    TGF beta 2 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50153-ACR
    TGF beta 2 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50153-CF
    TGF beta 2 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50153-NF
    TGF beta 2 cDNA ORF Clone, Mouse, C-His tag MG50153-CH
    TGF beta 2 cDNA ORF Clone, Mouse, N-His tag MG50153-NH
    TGF beta 2 cDNA ORF Clone, Mouse, C-HA tag MG50153-CY
    TGF beta 2 cDNA ORF Clone, Mouse, N-HA tag MG50153-NY
    TGF beta 2 cDNA ORF Clone, Mouse, C-Myc tag MG50153-CM
    TGF beta 2 cDNA ORF Clone, Mouse, N-Myc tag MG50153-NM
    TGF beta 2 qPCR Primer Pairs, Mouse MP200183

    TGF beta 2 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    TGF beta 2 cDNA ORF Clone in Cloning Vector, Human HG10382-M
    TGF beta 2 cDNA ORF Clone, Human, untagged HG10382-UT
    TGF beta 2 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10382-ACGLN
    TGF beta 2 cDNA ORF Clone, Human, C-GFPSpark® tag HG10382-ACG
    TGF beta 2 cDNA ORF Clone, Human, C-OFPSpark® tag HG10382-ACR
    TGF beta 2 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10382-CF
    TGF beta 2 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10382-NF
    TGF beta 2 cDNA ORF Clone, Human, C-His tag HG10382-CH
    TGF beta 2 cDNA ORF Clone, Human, N-His tag HG10382-NH
    TGF beta 2 cDNA ORF Clone, Human, C-HA tag HG10382-CY
    TGF beta 2 cDNA ORF Clone, Human, N-HA tag HG10382-NY
    TGF beta 2 cDNA ORF Clone, Human, C-Myc tag HG10382-CM
    TGF beta 2 cDNA ORF Clone, Human, N-Myc tag HG10382-NM
    TGF beta 2 qPCR Primer Pairs, Human HP100416
    info info
    添加购物车成功! 添加购物车失败!