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Крыса Junctional Adhesion Molecule B Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка

ПаспортОбзорыСвязанные продуктыПротоколы
Rat JAM2 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_001034004.1
Размер кДНК:897bp
Описание кДНК:Full length Clone DNA of Rattus norvegicus junctional adhesion molecule 2 with C terminal HA tag.
Синоним гена:Jam2
Виды:Rat
переносчик:pCMV3-C-HA
Plasmid:
Участок рестрикции:
Последовательность меток:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Крыса Junctional Adhesion Molecule B Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка on other vectors
Крыса Junctional Adhesion Molecule B Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаRG80376-ACGRBS15400
Крыса Junctional Adhesion Molecule B Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаRG80376-ACRRBS15400
Крыса Junctional Adhesion Molecule B Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаRG80376-CFRBS13340
Крыса Junctional Adhesion Molecule B Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаRG80376-CHRBS13340
Крыса Junctional Adhesion Molecule B Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаRG80376-CMRBS13340
Крыса Junctional Adhesion Molecule B Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаRG80376-CYRBS13340
Крыса Junctional Adhesion Molecule B Джин клон кДНК в вектор клонированияRG80376-GRBS5130
Крыса Junctional Adhesion Molecule B Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаRG80376-NFRBS13340
Крыса Junctional Adhesion Molecule B Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаRG80376-NHRBS13340
Крыса Junctional Adhesion Molecule B Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаRG80376-NMRBS13340
Крыса Junctional Adhesion Molecule B Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаRG80376-NYRBS13340
Крыса Junctional Adhesion Molecule B Джин ORF экспрессии кДНК клона плазмидыRG80376-UTRBS13340
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Фон

Junctional adhesion molecule B (JAM-B), also known as Junctional adhesion molecule 2 (JAM2), Vascular endothelial junction-associated molecule (VE-JAM), and CD322, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily. It is prominently expressed on high endothelial venules. expression to be restricted to the high endothelial venule of tonsil and lymph nodes. The localization to the endothelium of arterioles in and around inflammatory and tumor foci. JAM-B can function as an adhesive ligand for the T cell line J45 and can interact with GM-CSF/IL-4-derived peripheral blood dendritic cells, circulating CD56(+) NK cells, circulating CD56(+)CD3(+) NK/T cells, and circulating CD56(+)CD3(+)CD8(+) cytolytic T cells. JAM-2 is expressed on high endothelial venules (HEVs) in human tonsil and on a subset of human leukocytes, suggesting that JAM-2 plays a central role in the regulation of transendothelial migration. It binds to very late activation antigen (VLA)-4, a leucocyte integrin that contributes to rolling and firm adhesion of lymphocytes to endothelial cells through binding to vascular cell adhesion molecule (VCAM)-1. JAM-B appears to contribute to leucocyte extravasation by facilitating not only transmigration but also rolling and adhesion. JAM-B acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.

Ссылки
  • Johnson-Lger CA, et al. (2002) Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration. Blood. 2100(7): 2479-86.
  • Liang TW, et al. (2002) Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3. J Immunol. 168(4): 1618-26.
  • Ludwig RJ, et al. (2009) Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrin. Immunology. 128(2): 196-205.
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    Каталог: RG80376-CY
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    Наличие2-3 weeks
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