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Крыса IL-9 Джин ORF экспрессии кДНК клона плазмиды, N-HA Метка

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Rat IL9 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_001105747.1
Размер кДНК:435bp
Описание кДНК:Full length Clone DNA of Rattus norvegicus interleukin 9 with N terminal HA tag.
Синоним гена:IL9
Виды:Rat
переносчик:pCMV3-SP-N-HA
Plasmid:
Участок рестрикции:
Последовательность меток:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Крыса IL-9 Джин ORF экспрессии кДНК клона плазмиды, N-HA Метка on other vectors
Крыса IL-9 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаRG80459-ACGRBS15400
Крыса IL-9 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаRG80459-ACRRBS15400
Крыса IL-9 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаRG80459-CFRBS13340
Крыса IL-9 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаRG80459-CHRBS13340
Крыса IL-9 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаRG80459-CMRBS13340
Крыса IL-9 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаRG80459-CYRBS13340
Крыса IL-9 Джин клон кДНК в вектор клонированияRG80459-GRBS5130
Крыса IL-9 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаRG80459-NFRBS13340
Крыса IL-9 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаRG80459-NHRBS13340
Крыса IL-9 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаRG80459-NMRBS13340
Крыса IL-9 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаRG80459-NYRBS13340
Крыса IL-9 Джин ORF экспрессии кДНК клона плазмидыRG80459-UTRBS13340
 Узнайте больше о векторов экспрессии,
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Фон

Interleukin 9, also known as IL-9, is a cytokine (cell signalling molecule) belonging to the group of interleukins. IL-9 is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL-9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. IL-9 is a key molecule that affects differentiation of TH17 cells and Treg function. IL-9 predominantly produced by TH17 cells, synergizes with TGF-β1 to differentiate naïve CD4+ T cells into TH17 cells, while IL-9 secretion by TH17 cells is regulated by IL-23. Interestingly, IL-9 enhances the suppressive functions of FoxP3+ CD4+ Treg cells in vitro, and absence of IL-9 signaling weakens the suppressive activity of nTregs in vivo, leading to an increase in effector cells and worsening of experimental autoimmune encephalomyelitis. The mechanism of IL-9 effects on TH17 and Tregs is through activation of STAT3 and STAT5 signaling. Our findings highlight a role of IL-9 as a regulator of pathogenic versus protective mechanisms of immune responses.

Ссылки
  • Elyaman W, et al. (2009) IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells. Proc Natl Acad Sci U S A. 106(31): 12885-90.
  • Dong Q, et al. (1999) IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice. Eur J Immunol. 29(7): 2130-9.
  • Kimura Y, et al. (1995) Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex. Int Immunol. 7(1): 115-20.
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    Каталог: RG80459-NY
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    Количество:+-
    Наличие2-3 weeks
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