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Крыса IL12B/IL-12B Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка

ПаспортОбзорыСвязанные продуктыПротоколы
Rat IL12B Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_022611.1
Размер кДНК:1008bp
Описание кДНК:Full length Clone DNA of Rattus norvegicus interleukin 12b with C terminal HA tag.
Синоним гена:Il12, Il12b
Виды:Rat
переносчик:pCMV3-C-HA
Plasmid:
Участок рестрикции:
Последовательность меток:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Крыса IL12B/IL-12B Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка on other vectors
Крыса IL12B/IL-12B Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаRG80352-ACGRBS15400
Крыса IL12B/IL-12B Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаRG80352-ACRRBS15400
Крыса IL12B/IL-12B Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаRG80352-CFRBS13340
Крыса IL12B/IL-12B Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаRG80352-CHRBS13340
Крыса IL12B/IL-12B Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаRG80352-CMRBS13340
Крыса IL12B/IL-12B Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаRG80352-CYRBS13340
Крыса IL12B/IL-12B Джин клон кДНК в вектор клонированияRG80352-GRBS5130
Крыса IL12B/IL-12B Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаRG80352-NFRBS13340
Крыса IL12B/IL-12B Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаRG80352-NHRBS13340
Крыса IL12B/IL-12B Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаRG80352-NMRBS13340
Крыса IL12B/IL-12B Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаRG80352-NYRBS13340
Крыса IL12B/IL-12B Джин ORF экспрессии кДНК клона плазмидыRG80352-UTRBS13340
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Фон

Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. IL12B/IL-12B is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. IL12B/IL-12B associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity.

Ссылки
  • Taoufik Y, et al. (1997) Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect. Blood. 89 (8): 2842-8.
  • Fantuzzi L, et al. (1996) Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: requirement of gamma interferon for IL-12 secretion. J Virol. 70 (6): 4121-4.
  • Aragane Y, et al. (1995) IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol. 153 (12): 5366-72.
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    Каталог: RG80352-CY
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    Наличие2-3 weeks
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