The eukaryotic translation initiation factor 4E (eIF4E), is a limiting component of the eIF4F complex which is a critical determinant for the translation of mRNAs. We had shown that eIF4E availability and phosphorylation promote metastasis in mouse models of breast cancer by selectively augmenting the translation of mRNAs involved in invasion and metastasis. eIF4E phosphorylation is required for the chronic action of antidepressants, such as fluoxetine in mice. Elevated levels of eukaryotic initiation factor 4E (eIF4E) are implicated in neoplasia, with cumulative evidence pointing to its role in the etiopathogenesis of hematological diseases. eIF4E is a key focus in cancer research due to its role in controlling the translation of tumour-associated proteins, that drive an aggressive migratory phenotype.
eukaryotic translation initiation factor 4E