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Крыса CD131/CSF2RB/IL3RB/IL5RB Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка

ПаспортОбзорыСвязанные продуктыПротоколы
Rat CSF2RB Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_133555.1
Размер кДНК:2691bp
Описание кДНК:Full length Clone DNA of Rattus norvegicus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) with C terminal HA tag.
Синоним гена:Csf2rb1, Csf2rb
Виды:Rat
переносчик:pCMV3-C-HA
Plasmid:
Участок рестрикции:
Последовательность меток:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Крыса CD131/CSF2RB/IL3RB/IL5RB Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка on other vectors
Крыса CD131/CSF2RB/IL3RB/IL5RB Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаRG80323-ACGRBS22240
Крыса CD131/CSF2RB/IL3RB/IL5RB Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаRG80323-ACRRBS22240
Крыса CD131/CSF2RB/IL3RB/IL5RB Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаRG80323-CFRBS20190
Крыса CD131/CSF2RB/IL3RB/IL5RB Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаRG80323-CHRBS20190
Крыса CD131/CSF2RB/IL3RB/IL5RB Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаRG80323-CMRBS20190
Крыса CD131/CSF2RB/IL3RB/IL5RB Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаRG80323-CYRBS20190
Крыса CD131/CSF2RB/IL3RB/IL5RB Джин клон кДНК в вектор клонированияRG80323-GRBS5130
Крыса CD131/CSF2RB/IL3RB/IL5RB Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаRG80323-NFRBS20190
Крыса CD131/CSF2RB/IL3RB/IL5RB Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаRG80323-NHRBS20190
Крыса CD131/CSF2RB/IL3RB/IL5RB Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаRG80323-NMRBS20190
Крыса CD131/CSF2RB/IL3RB/IL5RB Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаRG80323-NYRBS20190
Крыса CD131/CSF2RB/IL3RB/IL5RB Джин ORF экспрессии кДНК клона плазмидыRG80323-UTRBS20190
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Product nameProduct name
Фон

Colony stimulating factor 2 receptor, beta, low-affinity (CSF2RB) also known as CD131 antigen (CD131), cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta-chain, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (IL3RB), is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this protein have been reported to be associated with protein alveolar proteinosis (PAP). CD131 belongs to the type I cytokine receptor family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Defects in CD131/CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5). SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.

Ссылки
  • Selleri S, et al. (2008) GM-CSF/IL-3/IL-5 receptor common beta chain (CD131) expression as a biomarker of antigen-stimulated CD8+ T cells. J Transl Med. 6:17.
  • Woodcock, et al. (1994) Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 13(21): 5176-85.
  • Dirksen U, et al. (1997) Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression. J Clin Invest. 100(9): 2211-7.
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    Каталог: RG80323-CY
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    Количество:+-
    Наличие2-3 weeks
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