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Крыса KSP-Cadherin/Cadherin-16 Джин ORF экспрессии кДНК клона плазмиды, C-His Метка

ПаспортОбзорыСвязанные продуктыПротоколы
Rat CDH16 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_001012055.1
Размер кДНК:2493bp
Описание кДНК:Full length Clone DNA of Rattus norvegicus cadherin 16 with C terminal His tag.
Синоним гена:Cdh16
Виды:Rat
переносчик:pCMV3-C-His
Plasmid:
Участок рестрикции:
Последовательность меток:His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
His Tag Info

A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.

Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.

Крыса KSP-Cadherin/Cadherin-16 Джин ORF экспрессии кДНК клона плазмиды, C-His Метка on other vectors
Крыса KSP-Cadherin/Cadherin-16 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаRG80282-ACGRBS16760
Крыса KSP-Cadherin/Cadherin-16 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаRG80282-ACRRBS16760
Крыса KSP-Cadherin/Cadherin-16 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаRG80282-CFRBS14710
Крыса KSP-Cadherin/Cadherin-16 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаRG80282-CHRBS14710
Крыса KSP-Cadherin/Cadherin-16 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаRG80282-CMRBS14710
Крыса KSP-Cadherin/Cadherin-16 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаRG80282-CYRBS14710
Крыса KSP-Cadherin/Cadherin-16 Джин клон кДНК в вектор клонированияRG80282-GRBS5130
Крыса KSP-Cadherin/Cadherin-16 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаRG80282-NFRBS14710
Крыса KSP-Cadherin/Cadherin-16 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаRG80282-NHRBS14710
Крыса KSP-Cadherin/Cadherin-16 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаRG80282-NMRBS14710
Крыса KSP-Cadherin/Cadherin-16 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаRG80282-NYRBS14710
Крыса KSP-Cadherin/Cadherin-16 Джин ORF экспрессии кДНК клона плазмидыRG80282-UTRBS14710
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Фон

KSP-Cadherin/Cadherin-16 is a member of the cadherin superfamily, calcium-dependent, membrane-associated glycoproteins. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. KSP-Cadherin/Cadherin-16 can be detected at later stages of tubulogenesis during human renal development and in the distal tubules of adult kidneys, no expression was found by immunohistochemistry or Western blot analysis in RCC tumour tissues and several RCC cell lines. However, despite the lack of protein expression, mRNA synthesis of KSP-Cadherin/Cadherin-16 could be detected by reverse transcriptase-polymerase chain reaction analysis in all RCC tissues and most of the RCC cell lines studied, although at a reduced level. The loss of KSP-Cadherin/Cadherin-16 protein was only observed in the malignant part of the tumour kidneys, whereas in the normal part of the affected kidneys KSP-Cadherin/Cadherin-16 expression was clearly detected. These results indicate a downregulation of Ksp-cadherin in RCC and suggest a role for this cell adhesion molecule in tumour suppression.

Ссылки
  • Thomson RB, et al. (1999) Immunolocalization of Ksp-cadherin in the adult and developing rabbit kidney. Am J Physiol. 277 (1): 146-56.
  • Thedieck C, et al. (2005) Expression of Ksp-cadherin during kidney development and in renal cell carcinoma. Br J Cancer. 92(11): 2010-7.
  • Bai Y, et al. (2002) Regulation of kidney-specific Ksp-cadherin gene promoter by hepatocyte nuclear factor-1beta. Am J Physiol Renal Physiol. 283(4): 839-51.
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    Каталог: RG80282-CH
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    Наличие2-3 weeks
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