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Крыса CD164 Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка

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Rat CD164 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_031812.1
Размер кДНК:588bp
Описание кДНК:Full length Clone DNA of Rattus norvegicus CD164 molecule, sialomucin with C terminal HA tag.
Синоним гена:MGC-24v, Cd164
Виды:Rat
переносчик:pCMV3-C-HA
Plasmid:
Участок рестрикции:
Последовательность меток:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Крыса CD164 Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка on other vectors
Крыса CD164 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаRG80354-ACGRBS15400
Крыса CD164 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаRG80354-ACRRBS15400
Крыса CD164 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаRG80354-CFRBS13340
Крыса CD164 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаRG80354-CHRBS13340
Крыса CD164 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаRG80354-CMRBS13340
Крыса CD164 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаRG80354-CYRBS13340
Крыса CD164 Джин клон кДНК в вектор клонированияRG80354-GRBS5130
Крыса CD164 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаRG80354-NFRBS13340
Крыса CD164 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаRG80354-NHRBS13340
Крыса CD164 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаRG80354-NMRBS13340
Крыса CD164 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаRG80354-NYRBS13340
Крыса CD164 Джин ORF экспрессии кДНК клона плазмидыRG80354-UTRBS13340
 Узнайте больше о векторов экспрессии,
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Фон

Sialomucin core protein 24 also known as endolyn or CD164 (cluster of differentiation 164) is a novel 80- to 90-kD mucin-like molecule expressed by human CD34+ hematopoietic progenitor cells. Isoform 1 and isoform 3 of CD164 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 of CD164 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells. CD164 belongs to the CD164 family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. CD164 may play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. CD164 promotes myogenesis by enhancing CXCR4-dependent cell motility. This protein positively regulates myoblast migration and promotes myoblast fusion into myotubes. CD164 may play a key role in hematopoiesis by facilitating the adhesion of CD34+ cells to bone marrow stroma and by negatively regulating CD34+hematopoietic progenitor cell growth.

Ссылки
  • McGuckin CP, et al. (2003) Colocalization analysis of sialomucins CD34 and CD164. Stem Cells. 21(2): 162-70.
  • Doyonnas R, et al. (2000) CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor. J Immunol. 165(2): 840-51.
  • Zannettino AC, et al. (1998) The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis. Blood. 92(8): 2613-28.
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    Каталог: RG80354-CY
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