OTUB2 (Protein | Antibody | cDNA Clone | ELISA Kit)

All OTUB2 reagents are produced in house and quality controlled, including 3 OTUB2 Antibody, 1 OTUB2 Gene, 1 OTUB2 Protein. All OTUB2 reagents are ready to use.

OTUB2 Protein (1)

    OTUB2 Antibody (3)

      OTUB2 cDNA Clone (1)

      NM_023112.3

      In expression vector

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      OTUB2 Background

      Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded β-sheet sandwiched in between a small helical amino-terminal region consisting of α1 and α2, and a large helical region comprised of α3-α1. Like other DUBs, otubain 2 (OTUB2) cleaves proteins precisely at the ubiquitin-protein bond so that ubiquitylation process can be reversed and regulated. Otubain 2 (OTUB2)'s active-site cleft is sterically occluded by a novel loop conformation resulting in an oxyanion hole, which consists uniquely of backbone amides. Furthermore, the residues that orient and stabilize the active-site histidine of otubain 2 (OTUB2) are different from other cysteine proteases. This reorganization of the active-site topology provides a possible explanation for the low turnover and substrate specificity of the otubains.

      OTUB2 References

      • Balakirev MY, et al. (2003) Otubains: a new family of cysteine proteases in the ubiquitin pathway. EMBO Rep 4 (5): 517-22.
      • Nanao MH. (2004) Crystal structure of human otubain 2. EMBO reports. 5: 783-8.