Anti-LOX-1 Antibody

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Anti-LOX-1 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-LOX-1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human LOX-1
Immunogen
Recombinant Human OLR1 / LOX1 protein (Catalog#10585-H07H)
Preparation
Produced in rabbits immunized with purified, recombinant Human OLR1 / LOX1 (rh OLR1 / LOX1; Catalog#10585-H07H; P78380; Ser 61-Gln 273). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-LOX-1 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-LOX-1 Antibody: Alternative Names

Anti-CLEC8A Antibody; Anti-LOX1 Antibody; Anti-LOXIN Antibody; Anti-OLR1 Antibody; Anti-SCARE1 Antibody; Anti-SLOX1 Antibody

LOX-1 Background Information

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as lectin-type oxidized LDL receptor 1 (LOX1), is a receptor protein that belongs to the C-type lectin superfamily. LOX1 is a multi-ligand receptor originally identified as the endothelial oxidized LDL receptor. OLR1 / LOX1 was isolated from an aortic endothelial cell, and recently it has been discovered in macrophages and vascular smooth muscle cells in artery vessels. The expression of LOX1 is inducted by inflammatory stimuli and oxidative stimuli. This protein binds, internalizes and degrades oxidized low-density lipoprotein. LOX1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2. In clinical, LOX1 is thought to be involved in the development of atherosclerotic lesions.
Full Name
oxidized low density lipoprotein (lectin-like) receptor 1
References
  • Hinagata J, et al. (2006) Oxidized LDL receptor LOX-1 is involved in neointimal hyperplasia after balloon arterial injury in a rat model. Cardiovasc Res. 69 (1): 263-71.
  • Melan MA, et al. (1994) The LOX1 Gene of Arabidopsis Is Temporally and Spatially Regulated in Germinating Seedlings. Plant Physiol. 105 (1): 385-93.
  • Saito A, et al. (2010) Relationship between lectin-like oxidized low-density lipoprotein receptor 1 expression and preoperative echogenic findings of vulnerable carotid plaque. Acta Neurochir (Wien). 152 (4): 589-95.
  • Human Cytomegalovirus-Encoded miR-US25-1 Aggravates the Oxidised Low Density Lipoprotein-Induced Apoptosis of Endothelial Cells
    Author
    Fan, J;Zhang, W;Liu, Q;
    Year
    2014
    Journal
    BioMed Research International
    Application
    WB
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