After search, choose a molecule or a kind of categories listed in the left to narrow down your filter. If you have any problems, please contact us!

Быстрый заказ

Text Size:AAA

Мышь NRN1/Neuritin 1 Джин клон кДНК в вектор клонирования

ПаспортОбзорыСвязанные продуктыПротоколы
Mouse NRN1 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_153529.2
Размер кДНК:429bp
Описание кДНК:Full length Clone DNA of Mus musculus neuritin 1.
Синоним гена:Nrn, Cpg15, 0710008J23Rik
Виды:Mouse
переносчик:pGEM-T Vector
Plasmid:pGEM-mNRN1
Участок рестрикции:
Последовательность меток:
Описание последовательности:Identical with the Gene Bank Ref. ID sequence except for the point mutation: 212A>G(D71G).
Sequencing primers:SP6 and T7 or M13-47 and RV-M
Promoter:
Application:
Antibiotic in E.coli:Ampicilin
Antibiotic in mammalian cell:
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
pGEM-T Vector Information

The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.

pGEM-T Simple Usage Suggestion:

The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.

Vector Sequence Download
Мышь NRN1/Neuritin 1 Джин клон кДНК в вектор клонирования on other vectors
Мышь NRN1/Neuritin 1 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаMG52152-ACGRBS15400
Мышь NRN1/Neuritin 1 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаMG52152-ACRRBS15400
Мышь NRN1/Neuritin 1 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаMG52152-CFRBS13340
Мышь NRN1/Neuritin 1 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаMG52152-CHRBS13340
Мышь NRN1/Neuritin 1 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаMG52152-CMRBS13340
Мышь NRN1/Neuritin 1 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаMG52152-CYRBS13340
Мышь NRN1/Neuritin 1 Джин клон кДНК в вектор клонированияMG52152-GRBS5130
Мышь NRN1/Neuritin 1 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаMG52152-NFRBS13340
Мышь NRN1/Neuritin 1 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаMG52152-NHRBS13340
Мышь NRN1/Neuritin 1 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаMG52152-NMRBS13340
Мышь NRN1/Neuritin 1 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаMG52152-NYRBS13340
Мышь NRN1/Neuritin 1 Джин ORF экспрессии кДНК клона плазмидыMG52152-UTRBS13340
 Узнайте больше о векторов экспрессии,
Product nameProduct name
Фон

Neuritin 1 (NRN1) is a member of neuritin family. Neuritin is a glycosylphosphatidylinositol- anchored protein induced by neural activity. It is expressed in postmitotic-differentiating neurons of the developing nervous system and a population of small-diameter neurons in the dorsal root ganglia and was anterogradely and retrogradely transported. Neuritin message is induced by neuronal activity and by the activity-regulated neurotrophins BDNF, nerve growth factor (NGF) and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic hippocampal and cortical cultures. Thus, neuritin is considered as a downstream effector of activity-induced neurite outgrowth. In clinical, neuritin levels in diabetes were reduced in both dorsal root ganglia and sciatic nerve of rats, and these deficits were reversed in vivo by treatment with NGF. This manipulation of neuritin levels in diabetes may provide a potential target for the therapeutic intervention in the management of neuropathy.

Ссылки
  • Karamoysoyli E, et al. (2008) Neuritin mediates nerve growth factor-induced axonal regeneration and is deficient in experimental diabetic neuropathy. Diabetes. 57(1): 181-9.
  • Naeve GS, et al. (1997) Neuritin: A gene induced by neural activity and neurotrophins that promotes neuritogenesis. Proc Natl Acad Sci U S A. 94(6): 2648-2653.
  • Kojima N, et al. (2005) Expression of neuritin during liver maturation and regeneration. FEBS Lett. 579(21): 4562-6.
  • All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Внимание: все продукты «ПРЕДНАЗНАЧЕНЫ ИСКЛЮЧИТЕЛЬНО ДЛЯ ИССЛЕДОВАНИЙ И НЕ ПРЕДНАЗНАЧЕНЫ ДЛЯ ДИАГНОСТИКИ ИЛИ ТЕРАПЕВТИЧЕСКОГО ЛЕЧЕНИЯ».