Anti-NAALADL1 Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Mouse
Recombinant Mouse NAALADL1 protein (Catalog#50937-M07H)
Produced in rabbits immunized with purified, recombinant Mouse NAALADL1 (rM NAALADL1; Catalog#50937-M07H; Q7M758; Pro29-Leu745). NAALADL1 specific IgG was purified by Mouse NAALADL1 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Immunochemical staining of mouse NAALADL1 in mouse brain with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Anti-NAALADL1 Antibody: Alternative Names
Anti-Gm964 Antibody; Anti-Naaladasel Antibody
NAALADL1 Background Information
N-acetylated-alpha-linked acidic dipeptidase-like protein, also known as NAALADL1, NAALADase L, and Ileal dipeptidylpeptidase, is a Single-pass type I I membrane protein and a member of the peptidase M28 family and M28B subfamily. NAALADase L is mainly expressed in the distal small intestine. It is also expressed in the spleen and testis and Weakly expressed in the brain, locating mainly to the brain stem, amygdala, thalamus and ventral striatum. NAALADase L is a chloride-activated, membrane bound, metallopeptidase that cleaves the endogenous neuropeptide N-acetyl-aspartyl-glutamate (NAAG). NAAG acts as a partial NMDA agonist as well as a full agonist at the presynaptic metabotropic glutamate receptor 3 (mGluR3), where it acts to reduce glutamate release. NAALADase L also exhibits a dipeptidyl-peptidase IV type activity. NAALADase inhibition may be a novel therapeutic approach to reduce or inhibit heightened aggressiveness, and possibly to treat aggressive behavior associated with psychiatric disorders.
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