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Мышь TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка

ПаспортОбзорыСвязанные продуктыПротоколы
Mouse TNFRSF11A Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_009399.3
Размер кДНК:1878bp
Описание кДНК:Full length Clone DNA of Mus musculus tumor necrosis factor receptor superfamily, member 11a with C terminal HA tag.
Синоним гена:OFE, ODFR, Rank, Ly109, mRANK, TRANCE-R
Виды:Mouse
переносчик:pCMV3-C-HA
Plasmid:
Участок рестрикции:
Последовательность меток:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Мышь TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка on other vectors
Мышь TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаMG50490-ACGRBS16760
Мышь TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаMG50490-ACRRBS16760
Мышь TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаMG50490-CFRBS14710
Мышь TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаMG50490-CHRBS14710
Мышь TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаMG50490-CMRBS14710
Мышь TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаMG50490-CYRBS14710
Мышь TNFRSF11A Джин клон кДНК в вектор клонированияMG50490-MRBS5130
Мышь TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаMG50490-NFRBS14710
Мышь TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаMG50490-NHRBS14710
Мышь TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаMG50490-NMRBS14710
Мышь TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаMG50490-NYRBS14710
Мышь TNFRSF11A Джин ORF экспрессии кДНК клона плазмидыMG50490-UTRBS14710
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Фон

TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. Defects in TNFRSF11A can cause familial expansile osteolysis (FEO). FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. Defects in TNFRSF11A also can cause Paget disease of bone type 2 (PDB2). PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Defects in TNFRSF11A are the cause of osteopetrosis autosomal recessive type 7 which characterized by abnormally dense bone, due to defective resorption of immature bone.

Ссылки
  • Darnay B G, et al. (1998) Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. J Biol Chem. 273(32):20551-5.
  • Darnay B G, et al. (1999) Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. J Biol Chem. 274(12):7724-31.
  • Galibert L, et al. (1998) The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. J Biol Chem. 273(51):34120-7.
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    Каталог: MG50490-CY
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    Наличие2-3 weeks
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