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Мышь TGFBR3 / Betaglycan Джин ORF экспрессии кДНК клона плазмиды, N-HA Метка

ПаспортОбзорыСвязанные продуктыПротоколы
Mouse TGFBR3 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_011578.2
Размер кДНК:2553bp
Описание кДНК:Full length Clone DNA of Mus musculus transforming growth factor, beta receptor III with N terminal HA tag.
Синоним гена:TBRIII, AU015626, AW215636, 1110036H20Rik, Tgfbr3
Виды:Mouse
переносчик:pCMV3-SP-N-HA
Plasmid:
Участок рестрикции:
Последовательность меток:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Мышь TGFBR3 / Betaglycan Джин ORF экспрессии кДНК клона плазмиды, N-HA Метка on other vectors
Мышь TGFBR3 / Betaglycan Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаMG50542-ACGRBS22238
Мышь TGFBR3 / Betaglycan Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаMG50542-ACRRBS22238
Мышь TGFBR3 / Betaglycan Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаMG50542-CFRBS20185
Мышь TGFBR3 / Betaglycan Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаMG50542-CHRBS20185
Мышь TGFBR3 / Betaglycan Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаMG50542-CMRBS20185
Мышь TGFBR3 / Betaglycan Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаMG50542-CYRBS20185
Мышь TGFBR3 / Betaglycan Джин клон кДНК в вектор клонированияMG50542-MRBS5132
Мышь TGFBR3 / Betaglycan Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаMG50542-NFRBS20185
Мышь TGFBR3 / Betaglycan Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаMG50542-NHRBS20185
Мышь TGFBR3 / Betaglycan Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаMG50542-NMRBS20185
Мышь TGFBR3 / Betaglycan Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаMG50542-NYRBS20185
Мышь TGFBR3 / Betaglycan Джин ORF экспрессии кДНК клона плазмидыMG50542-UTRBS20185
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Фон

Betaglycan also known as transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan. TGFBR3 is a transforming growth factor (TGF)-beta type III receptor. This receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. TGFBR3 is the TGF-β component most commonly downregulated among localized human prostate cancer studies. TGFBR3 knockdown led to focus formation and enhanced expression of CD133, a marker found on prostate cancer stem cells. TGFBR3 is an accessory receptor that binds to and modulates the activities of both transforming growth factor-beta (TGFβ) and inhibin, two members of the TGFβ superfamily of growth factors that regulate many aspects of reproductive biology. TGFBR3 is known to be expressed in adult testis and ovary, but little is known about this receptor during gonadogenesis.

Ссылки
  • Johnson DW, et al. (1996) Assignment of human transforming growth factor-beta type I and type III receptor genes (TGFBR1 and TGFBR3) to 9q33-q34 and 1p32-p33, respectively. Genomics. 28 (2): 356-7.
  • Rotzer D, et al. (2001) Type III TGF-beta receptor-independent signalling of TGF-beta2 via T betaRII-B, an alternatively spliced TGF- type II receptor. EMBO J. 20 (3): 480-90.
  • Gao J, et al. (1999) Expression of transforming growth factor-beta receptors types II and III within various cells in the rat periodontium. J Periodont Res. 34 (2): 113-22.
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    Каталог: MG50542-NY
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