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Мышь SIGIRR/TIR8 Джин ORF экспрессии кДНК клона плазмиды, N-His Метка

    ПаспортОбзорыСвязанные продуктыПротоколы
    Мышь SIGIRR Информация о продукте «Клон cDNA»
    Gene_bank_ref_id:NM_023059.3
    Размер кДНК:1230bp
    Описание кДНК:Full length Clone DNA of Mus musculus single immunoglobulin and toll-interleukin 1 receptor (TIR) domain with N terminal His tag.
    Синоним гена:TIR8, AI256711, MGC102426
    Виды:Mouse
    переносчик:pCMV3-SP-N-His
    Plasmid:
    Участок рестрикции:
    Последовательность меток:His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
    Описание последовательности:
    Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
    ( We provide with SIGIRR qPCR primers for gene expression analysis, MP200152 )
    Promoter:Enhanced CMV mammalian cell promoter
    Application:Stable or Transient mammalian expression
    Antibiotic in E.coli:Kanamycin
    Antibiotic in mammalian cell:Hygromycin
    Shipping_carrier:Each tube contains lyophilized plasmid.
    Склад:The lyophilized plasmid can be stored at room temperature for three months.
    His Tag Info

    A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.

    Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.

    Мышь SIGIRR/TIR8 Джин ORF экспрессии кДНК клона плазмиды, N-His Метка on other vectors
    Мышь SIGIRR/TIR8 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаMG50122-ACGRBS15400
    Мышь SIGIRR/TIR8 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаMG50122-ACRRBS15400
    Мышь SIGIRR/TIR8 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаMG50122-CFRBS13340
    Мышь SIGIRR/TIR8 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаMG50122-CHRBS13340
    Мышь SIGIRR/TIR8 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаMG50122-CMRBS13340
    Мышь SIGIRR/TIR8 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаMG50122-CYRBS13340
    Мышь SIGIRR/TIR8 Джин клон кДНК в вектор клонированияMG50122-MRBS5130
    Мышь SIGIRR/TIR8 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаMG50122-NFRBS13340
    Мышь SIGIRR/TIR8 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаMG50122-NHRBS13340
    Мышь SIGIRR/TIR8 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаMG50122-NMRBS13340
    Мышь SIGIRR/TIR8 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаMG50122-NYRBS13340
    Мышь SIGIRR/TIR8 Джин ORF экспрессии кДНК клона плазмидыMG50122-UTRBS13340
     Узнайте больше о векторов экспрессии,
    Product nameProduct name
    Фон

    Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR/TIR8 has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. SIGIRR/TIR8 was mainly expressed in mouse and human epithelial tissues such as kidney, lung and gut. Resting and activated T and B lymphocytes and monocytes-macrophages expressed little or no SIGIRR/TIR8, with the exception of the mouse GG2EE macrophage line. Inflammation is enhanced in SIGIRR-deficient mice. SIGIRR negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice, as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge.

    Ссылки
  • Wald D, et al. (2003) SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 4(9): 920-7.
  • Polentarutti N, et al. (2003) Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. Eur Cytokine Netw. 14(4): 211-8.
  • Wald D, et al. (2003) SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 4(9): 920-7.
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    Каталог: MG50122-NH
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