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Мышь PTPN2/TC-PTP Джин ORF экспрессии кДНК клона плазмиды, N-Myc Метка

ПаспортОбзорыСвязанные продуктыПротоколы
Mouse PTPN2 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_001127177.1
Размер кДНК:1221bp
Описание кДНК:Full length Clone DNA of Mus musculus protein tyrosine phosphatase, non-receptor type 2 with N terminal Myc tag.
Синоним гена:Ptpt, TC-PTP, AI325124, Ptpn2
Виды:Mouse
переносчик:pCMV3-SP-N-Myc
Plasmid:
Участок рестрикции:
Последовательность меток:Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
Myc Tag Info

A myc tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting.

The peptide sequence of the myc-tag is: N-EQKLISEEDL-C (1202 Da). It can be fused to the C-terminus and the N-terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway.

Мышь PTPN2/TC-PTP Джин ORF экспрессии кДНК клона плазмиды, N-Myc Метка on other vectors
Мышь PTPN2/TC-PTP Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаMG50800-ACGRBS15400
Мышь PTPN2/TC-PTP Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаMG50800-ACRRBS15400
Мышь PTPN2/TC-PTP Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаMG50800-CFRBS13340
Мышь PTPN2/TC-PTP Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаMG50800-CHRBS13340
Мышь PTPN2/TC-PTP Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаMG50800-CMRBS13340
Мышь PTPN2/TC-PTP Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаMG50800-CYRBS13340
Мышь PTPN2/TC-PTP Джин клон кДНК в вектор клонированияMG50800-GRBS5130
Мышь PTPN2/TC-PTP Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаMG50800-NFRBS13340
Мышь PTPN2/TC-PTP Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаMG50800-NHRBS13340
Мышь PTPN2/TC-PTP Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаMG50800-NMRBS13340
Мышь PTPN2/TC-PTP Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаMG50800-NYRBS13340
Мышь PTPN2/TC-PTP Джин ORF экспрессии кДНК клона плазмидыMG50800-UTRBS13340
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Фон

Tyrosine-protein phosphatase non-receptor type 2, also known as T-cell protein-tyrosine phosphatase, PTPN2 and PTPT, is a cytoplasm protein which belongs to the protein-tyrosine phosphatase family and Non-receptor class 1 subfamily. Members of the protein tyrosine phosphatase ( PTP ) family share a highly conserved catalytic motif, which is essential for the catalytic activity. TC-PTP / PTPN2 is a cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins. The expression of TC-PTP / PTPN2 plays a role of tumor suppressor and may modulate response to treatment. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. TC-PTP / PTPN2 is an enzyme that is essential for the proper functioning of the immune system and that participates in the control of cell proliferation, and inflammation. TC-PTP / PTPN2 was identified as a negative regulator of NUP214-ABL1 kinase activity.

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Каталог: MG50800-NM
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Количество:+-
Наличие2-3 weeks
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