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Мышь Neuropilin-1/NRP1/CD304 Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка

ПаспортОбзорыСвязанные продуктыПротоколы
Mouse NRP1 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_008737.1
Размер кДНК:2772bp
Описание кДНК:Full length Clone DNA of Mus musculus Neuropilin 1 with C terminal HA tag.
Синоним гена:Nrp, NP-1, Npn1, NPN-1, C530029I03, Nrp1
Виды:Mouse
переносчик:pCMV3-C-HA
Plasmid:
Участок рестрикции:
Последовательность меток:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Мышь Neuropilin-1/NRP1/CD304 Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка on other vectors
Мышь Neuropilin-1/NRP1/CD304 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаMG50509-ACGRBS22240
Мышь Neuropilin-1/NRP1/CD304 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаMG50509-ACRRBS22240
Мышь Neuropilin-1/NRP1/CD304 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаMG50509-CFRBS20190
Мышь Neuropilin-1/NRP1/CD304 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаMG50509-CHRBS20190
Мышь Neuropilin-1/NRP1/CD304 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаMG50509-CMRBS20190
Мышь Neuropilin-1/NRP1/CD304 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаMG50509-CYRBS20190
Мышь Neuropilin-1/NRP1/CD304 Джин клон кДНК в вектор клонированияMG50509-MRBS5130
Мышь Neuropilin-1/NRP1/CD304 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаMG50509-NFRBS20190
Мышь Neuropilin-1/NRP1/CD304 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаMG50509-NHRBS20190
Мышь Neuropilin-1/NRP1/CD304 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаMG50509-NMRBS20190
Мышь Neuropilin-1/NRP1/CD304 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаMG50509-NYRBS20190
Мышь Neuropilin-1/NRP1/CD304 Джин ORF экспрессии кДНК клона плазмидыMG50509-UTRBS20190
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Фон

Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologues, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is divided into four domains, CUB (a1/a2) domain, FV/FVIII (b1/b2) domain, MAM (c) domain, and (d) domain that contains a transmembrane and a short cytoplasmic region. Neuropilin-1 (NRP1) acts as a receptor for two different extracellular ligands, class 3 semaphorins and specific isoforms of vascular endothelial growth factor. The functions of NRP1 and NRP2 have been extensively studied in neurons where they act in axon guidance and in endothelial cells where they promote angiogenesis and cell migration. Neuropilin-1 is likely to mediate contacts between the dendritic cells and the T lymphocytes via homotypic interactions and is essential for the initiation of the primary immune response. NRP1 is a co-receptor for VEGF receptor-2 (VEGFR2) that enhances the binding of VEGF165 to VEGFR2 and VEGF165-mediated chemotaxis. NRP1 expression is regulated in EC by tumor necrosis factor-alpha, the transcription factors dHAND and Ets-1, and vascular injury. NRP1 upregulation is positively correlated with the progression of various tumors. Overexpression of NRPI in rat tumor cells results in enlarged tumors and substantially enhanced tumor angiogenesis. On the other hand, soluble NRP1 (sNRP1) is an antagonist of tumor angiogenesis.

Ссылки
  • Nakamura F, et al. (2002) Structural and functional relation of neuropilins. Adv Exp Med Biol. 515: 55-69.
  • Romeo PH, et al. (2002) Neuropilin-1 in the immune system. Adv Exp Med Biol. 515: 49-54.
  • Klagsbrun M, et al. (2002) The role of neuropilin in vascular and tumor biology. Adv Exp Med Biol. 515: 33-48.
  • Staton CA, et al. (2007) Neuropilins in physiological and pathological angiogenesis. J Pathol. 212(3): 237-48.
  • Bagri A, et al. (2009) Neuropilins in tumor biology. Clin Cancer Res. 15(6): 1860-4.
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    Каталог: MG50509-CY
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    Наличие2-3 weeks
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