KRT6A/Cytokeratin6A cDNA ORF Clone in Cloning Vector, Mouse

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KRT6A/Cytokeratin6A cDNA ORF Clone in Cloning Vector, Mouse: General Information

Gene
Species
Mouse
NCBI Ref Seq
RefSeq ORF Size
1662 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 270C>T, 480C>T and 1089A>G not causing the amino acid variation.
Description
Full length Clone DNA of Mouse keratin 6A.
Plasmid
Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

KRT6A/Cytokeratin6A cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

KRT6A/Cytokeratin6A cDNA ORF Clone in Cloning Vector, Mouse: Alternative Names

2310016L08Rik cDNA ORF Clone, Mouse; Krt2-6a cDNA ORF Clone, Mouse; Krt2-6c cDNA ORF Clone, Mouse; MK6a cDNA ORF Clone, Mouse; mK6[a] cDNA ORF Clone, Mouse

KRT6A/Cytokeratin6A Background Information

Mutations in the KRT6A or KRT16 gene cause pachyonychia congenita type 1 (PC-1), while mutations in KRT16 or KRT6C underlie focal palmoplantar keratoderma (FPPK).Pachyonychia congenita (PC) is an autosomal dominant, very rare keratin disorder caused by mutations in any of at least four genes (KRT6A, KRT6B, KRT16 or KRT17), which can lead to hypertrophic nail dystrophy and palmoplantar keratoderma, among other manifestations.A de novo missense mutation in the KRT6A gene, I462S, has been found in a sporadic PC-1 patient. The identification of this novel mutation in the KRT6A gene provides further evidence that mutation in the KRT6A gene causes PC-1 phenotype.
Full Name
keratin 6A, type II

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