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Мышь FLT3/CD135/FLK-2 Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка

ПаспортОбзорыСвязанные продуктыПротоколы
Mouse FLT3 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_010229.2
Размер кДНК:3003bp
Описание кДНК:Full length Clone DNA of Mus musculus FMS-like tyrosine kinase 3 with C terminal HA tag.
Синоним гена:Flk2, Ly72, wmfl, CD135, Flk-2, Flt-3, B230315G04
Виды:Mouse
переносчик:pCMV3-C-HA
Plasmid:
Участок рестрикции:
Последовательность меток:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Мышь FLT3/CD135/FLK-2 Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка on other vectors
Мышь FLT3/CD135/FLK-2 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаMG51119-ACGRBS22240
Мышь FLT3/CD135/FLK-2 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаMG51119-ACRRBS22240
Мышь FLT3/CD135/FLK-2 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаMG51119-CFRBS20190
Мышь FLT3/CD135/FLK-2 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаMG51119-CHRBS20190
Мышь FLT3/CD135/FLK-2 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаMG51119-CMRBS20190
Мышь FLT3/CD135/FLK-2 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаMG51119-CYRBS20190
Мышь FLT3/CD135/FLK-2 Джин клон кДНК в вектор клонированияMG51119-GRBS5130
Мышь FLT3/CD135/FLK-2 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаMG51119-NFRBS20190
Мышь FLT3/CD135/FLK-2 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаMG51119-NHRBS20190
Мышь FLT3/CD135/FLK-2 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаMG51119-NMRBS20190
Мышь FLT3/CD135/FLK-2 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаMG51119-NYRBS20190
Мышь FLT3/CD135/FLK-2 Джин ORF экспрессии кДНК клона плазмидыMG51119-UTRBS20190
 Узнайте больше о векторов экспрессии,
Product nameProduct name
Фон

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD135, also known as FLT-3, FLK-2, is a member of the CD system. CD135 is an important cell surface marker recognized by specific sets of antibodies to identify the types of hematopoietic (blood) progenitors in the bone marrow and it function to differentiate hematopoietic stem cells, which are CD135 negative, from multipotent progenitors, which are CD135 positive. CD135 is a receptor tyrosine kinase typeⅢ for the cytokine Flt3 ligand and activat signaling through second messengers by binding to Flt3. Signaling through CD135 is important for lymphocyte development. The encoding gene CD135 is a proto-oncogene to which mutations happened will lead to cancer such as leukemia.

Ссылки
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Bertho, et al. (2000) CD135 (Flk2 / Flt3) Expression by Human Thymocytes Delineates a Possible Role of FLT3-Ligand in T-Cell Precursor Proliferation and Differentiation. Scandinavian Journal of Immunology. 52 (1): 53-61.
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