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Мышь CTLA-4/CD152 Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка

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Мышь CTLA4 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_009843.3
Размер кДНК:654bp
Описание кДНК:Full length Clone DNA of Mus musculus cytotoxic T-lymphocyte-associated protein 4 with C terminal HA tag.
Синоним гена:Cd152, Ly-56, Ctla-4, Ctla4
Виды:Mouse
переносчик:pCMV3-C-HA
Plasmid:
Участок рестрикции:
Последовательность меток:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
( We provide with CTLA4 qPCR primers for gene expression analysis, MP200096 )
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Мышь CTLA-4/CD152 Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка on other vectors
Мышь CTLA-4/CD152 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаMG50503-ACGRBS15400
Мышь CTLA-4/CD152 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаMG50503-ACRRBS15400
Мышь CTLA-4/CD152 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаMG50503-CFRBS13340
Мышь CTLA-4/CD152 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаMG50503-CHRBS13340
Мышь CTLA-4/CD152 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаMG50503-CMRBS13340
Мышь CTLA-4/CD152 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаMG50503-CYRBS13340
Мышь CTLA-4/CD152 Джин клон кДНК в вектор клонированияMG50503-MRBS5130
Мышь CTLA-4/CD152 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаMG50503-NFRBS13340
Мышь CTLA-4/CD152 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаMG50503-NHRBS13340
Мышь CTLA-4/CD152 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаMG50503-NMRBS13340
Мышь CTLA-4/CD152 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаMG50503-NYRBS13340
Мышь CTLA-4/CD152 Джин ORF экспрессии кДНК клона плазмидыMG50503-UTRBS13340
 Узнайте больше о векторов экспрессии,
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Фон

Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins   CTLA4 / CD152 Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Ссылки
  • Slavik JM, et al. (1999) CD28/CTLA-4 and CD80/CD86 families: signaling and function. Immunol Res. 19(1): 1-24.
  • Holmberg D, et al. (2005) CTLA-4 (CD152) and its involvement in autoimmune disease. Autoimmunity. 38(3): 225-33.
  • Chin LT, et al. (2008) Immune intervention with monoclonal antibodies targeting CD152 (CTLA-4) for autoimmune and malignant diseases. Chang Gung Med J. 31(1): 1-15.
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    Каталог: MG50503-CY
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