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Мышь CD55/DAF Джин ORF экспрессии кДНК клона плазмиды, C-His Метка

ПаспортОбзорыСвязанные продуктыПротоколы
Mouse CD55 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_010016.2
Размер кДНК:1173bp
Описание кДНК:Full length Clone DNA of Mus musculus CD55 antigen with C terminal His tag.
Синоним гена:Daf, Daf1, Daf-GPI, GPI-DAF, Cd55
Виды:Mouse
переносчик:pCMV3-C-His
Plasmid:
Участок рестрикции:
Последовательность меток:His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
His Tag Info

A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.

Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.

Мышь CD55/DAF Джин ORF экспрессии кДНК клона плазмиды, C-His Метка on other vectors
Мышь CD55/DAF Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаMG50468-ACGRBS15400
Мышь CD55/DAF Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаMG50468-ACRRBS15400
Мышь CD55/DAF Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаMG50468-CFRBS13340
Мышь CD55/DAF Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаMG50468-CHRBS13340
Мышь CD55/DAF Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаMG50468-CMRBS13340
Мышь CD55/DAF Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаMG50468-CYRBS13340
Мышь CD55/DAF Джин клон кДНК в вектор клонированияMG50468-MRBS5130
Мышь CD55/DAF Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаMG50468-NFRBS13340
Мышь CD55/DAF Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаMG50468-NHRBS13340
Мышь CD55/DAF Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаMG50468-NMRBS13340
Мышь CD55/DAF Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаMG50468-NYRBS13340
Мышь CD55/DAF Джин ORF экспрессии кДНК клона плазмидыMG50468-UTRBS13340
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Фон

CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It is a major regulator of the alternative and classical pathways of complement activation and is expressed on all serum-exposed cells. CD55 is physiologically acting as an inhibitor of the complement system, but is also broadly expressed in malignant tumours. DAF seems to exert different functions beyond its immunological role such as promotion of tumorigenesis, decrease of complement mediated tumor cell lysis, autocrine loops for cell rescue and evasion of apoptosis, neoangiogenesis, invasiveness, cell motility. It is commonly hijacked by invading pathogens, including many enteroviruses and uropathogenic Escherichia coli, to promote cellular attachment prior to infection. This 70-75 kDa glycoprotein CD55 containing four SCR modules is involved in the regulation of the complement cascade. It inhibits complement activation by suppressing the function of C3/C5 convertases, thereby limiting local generation or deposition of C3a/C5a and membrane attack complex (MAC or C5b-9) production. DAF has been identified as a ligand for an activation-associated, seven-transmembrane lymphocyte receptor, CD97, which is a receptor mediating attachment and infection of several viruses and bacteria. In addition, it has been shown that DAF regulates the interplay between complement and T cell immunity in vivo, and thus may be implicated in immune and tumor biology.

Ссылки
  • Lea S. (2002) Interactions of CD55 with non-complement ligands. Biochem Soc Trans. 30(Pt 6): 1014-9.
  • Mikesch JH, et al. (2006) The expression and action of decay-accelerating factor (CD55) in human malignancies and cancer therapy. Cell Oncol. 28(5-6): 223-32.
  • Wang Y, et al. (2010) Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury. J Neuroinflammation. 7:24.
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    Каталог: MG50468-CH
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    Наличие2-3 weeks
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