BMP4 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag
Cat: MG50439-NF
Cat: MG50439-NF
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BMP4 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag: General Information
Gene
Species
Mouse
NCBI Ref Seq
RefSeq ORF Size
1227 bp
Description
Full length Clone DNA of Mouse bone morphogenetic protein 4 with N terminal Flag tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
Tag Sequence
FLAG Tag Sequence: GATTACAAGGATGACGACGATAAG
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
BMP4 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag: Alternative Names
Bmp-4 cDNA ORF Clone, Mouse; Bmp2b cDNA ORF Clone, Mouse; Bmp2b-1 cDNA ORF Clone, Mouse; Bmp2b1 cDNA ORF Clone, Mouse
BMP4 Background Information
BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human malignancies. BMP4 treatment promoted HCC cells proliferation and induced autophagy. Mechanistic study revealed that the induction of autophagy by BMP4 was mediated through activating the JNK1/Bcl2 pathway. And the JNK1 inhibitor and knockdown of JNK1 could attenuate autophagy induced by BMP4 and eliminated BMP4-promoted HCC cells growth. BMP4 promoted HCC proliferation by autophagy activation through JNK1/Bcl-2 signaling.
Full Name
bone morphogenetic protein 4
Research Areas
- Neuroscience>>Neurology process>>Growth and Development>>Axon Guidance>>Bone Morphogenetic Protein (BMP) & Receptor>>Bone Morphogenetic Protein (BMP)
- Stem Cells>>Cancer Stem Cells (CSCs)>>Cancer Stem Cell (CSC) Marker
- Stem Cells>>Stem Cell Differentiation Stage Marker>>Early Ectodermal Lineage Marker
- Developmental Biology>>Embryogenesis>>Germ Layer Formation>>Ectoderm Marker
- Stem Cells>>Stem Cell Growth Factors,Chemokines and Cytokines>>Embryonic Stem Cells (ESCs) and iPSCs Growth Factors, Chemokines and Cytokines
- Developmental Biology>>Organogenesis>>Gut development>>Gut specification
- Developmental Biology>>Organogenesis>>Excretory system development>>Kidney development
- Stem Cells>>Neural Stem Cells (NSCs)>>Mesenchymal Stem Cell (MSC) Marker
- Stem Cells>>Stem Cell Growth Factors,Chemokines and Cytokines>>Mesenchymal Stem Cells (MSCs) Growth Factors, Chemokines and Cytokines
- Developmental Biology>>Organogenesis>>Nervous system development
- Neuroscience>>Cell Type Marker in Neurodevelopment>>Neuronal Cell Markers>>Neural Crest Cell Marker
- Stem Cells>>Stem Cell Growth Factors,Chemokines and Cytokines>>Neural Stem Cells (NSCs) Growth Factors, Chemokines and Cytokines
- Developmental Biology>>Embryogenesis>>Embryonic Stem Cells>>Secreted
- Stem Cells>>Stem Cell Signaling Pathways>>TGF-beta Signaling Pathway
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