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Мышь BAFFR / TNFRSF13C / CD268 Джин ORF экспрессии кДНК клона плазмиды, C-Myc Метка

ПаспортОбзорыСвязанные продуктыПротоколы
Mouse TNFRSF13C Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_028075.2
Размер кДНК:528bp
Описание кДНК:Full length Clone DNA of Mus musculus tumor necrosis factor receptor superfamily, member 13c with C terminal Myc tag.
Синоним гена:Bcmd, Baffr, Bcmd1, BAFF-R, Bcmd-1, Lvis22, MGC123890, MGC123891, 2010006P15Rik, Tnfrsf13c
Виды:Mouse
переносчик:pCMV3-C-Myc
Plasmid:
Участок рестрикции:
Последовательность меток:Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
Myc Tag Info

A myc tag is a polypeptide protein tag derived from the c-myc gene product that can be added to a protein using recombinant DNA technology. It can be used for affinity chromatography, then used to separate recombinant, overexpressed protein from wild type protein expressed by the host organism. It can also be used in the isolation of protein complexes with multiple subunits.

A myc tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting.

The peptide sequence of the myc-tag is: N-EQKLISEEDL-C (1202 Da). It can be fused to the C-terminus and the N-terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway.

Мышь BAFFR / TNFRSF13C / CD268 Джин ORF экспрессии кДНК клона плазмиды, C-Myc Метка on other vectors
Мышь BAFFR / TNFRSF13C / CD268 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаMG50353-ACGRBS15400
Мышь BAFFR / TNFRSF13C / CD268 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаMG50353-ACRRBS15400
Мышь BAFFR / TNFRSF13C / CD268 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаMG50353-CFRBS13340
Мышь BAFFR / TNFRSF13C / CD268 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаMG50353-CHRBS13340
Мышь BAFFR / TNFRSF13C / CD268 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаMG50353-CMRBS13340
Мышь BAFFR / TNFRSF13C / CD268 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаMG50353-CYRBS13340
Мышь BAFFR / TNFRSF13C / CD268 Джин клон кДНК в вектор клонированияMG50353-MRBS5130
Мышь BAFFR / TNFRSF13C / CD268 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаMG50353-NFRBS13340
Мышь BAFFR / TNFRSF13C / CD268 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаMG50353-NHRBS13340
Мышь BAFFR / TNFRSF13C / CD268 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаMG50353-NMRBS13340
Мышь BAFFR / TNFRSF13C / CD268 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаMG50353-NYRBS13340
Мышь BAFFR / TNFRSF13C / CD268 Джин ORF экспрессии кДНК клона плазмидыMG50353-UTRBS13340
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Фон

Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. A tumor necrosis factor receptor (TNFR), or death receptor, is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). The receptor cooperates with an adaptor protein which is important in determining the outcome of the response. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors or tumour necrosis factor (TNFR), on their surface. Tumour necrosis factors (TNFR) detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery. It has been proposed that abnormally high levels of BAFFR/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

Ссылки
  • Ashkenazi A, et al. (1998) Death receptors: signaling and modulation. Science. 281(5381): 1305-8.
  • Losi CG, et al. (2005) Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency. J Clin Immunol. 25(5): 496-502.
  • Hentges KE, et al. (2002) Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22. Genomics. 80(2): 204-12.
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