LYRIC (Protein | Antibody | cDNA Clone | ELISA Kit)

All LYRIC reagents are produced in house and quality controlled, including 3 LYRIC Gene. All LYRIC reagents are ready to use.

LYRIC cDNA Clone (3)


In cloning vector

In lentiviral vector

In expression vector

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LYRIC Background

Metadherin (MTDH), also known as protein LYRIC or astrocyte elevated gene-1 protein (AEG-1), has emerged as an important oncogene protein that is overexpressed in all cancers analyzed so far. MTDH has been demonstrated to play a potential role in several significant aspects of tumor progression. The presence of the lung-homing domain of MTDH on tumor cells at the cell surface where it would be available to bind to vascular targets during metastasis has been confirmed. It has been reported that overexpression of MTDH is associated with progression of disease and poorer prognosis in breast cancer. It has been reported that MTDH overexpression could significantly enhance the invasion and migration of breast cancer cells by inducing epithelial-mesenchymal transition (EMT) that is a process in which polarized epithelial cells are converted into motile mesenchymal cells. Thus, during cancer development, MTDH is conducive to tumor dissemination and metastatic spread.

LYRIC References

  • Yoo BK, et al. (2011) Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology. Pharmacol Ther.130 (1) : 1-8.
  • Li XY, et al. (2011) Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition. Cancer Science. 102 (6) : 1151-7.
  • Su P, et al. (2010) Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue. Diagnostic Pathology. 5: 38.