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LFA-3 / CD58  Белок

All LFA-3 Reagents

Хозяин экспрессии: Human Cells  
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12409-H02H-50
12409-H02H-100
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Хозяин экспрессии: Human Cells  
  • Slide 1
12409-H08H-50
12409-H08H-100
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100 µg 
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Хозяин экспрессии: Human Cells  
  • Slide 1
90190-C08H-50
90190-C08H-100
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100 µg 
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LFA-3 / CD58 Связанные пути

    LFA-3 / CD58 Краткая информация и сведения о белках

    LFA-3 / CD58 Фон

    Краткая информация о гене: This gene encodes a member of the immunoglobulin superfamily. LFA-3 is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. LFA-3 is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
    General information above from NCBI
    Структура подгруппы: Interacts with CD2.
    Субклеточное местоположение: Isoform 1: Cell membrane; Single-pass type I membrane protein.
    Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor.
    Сходство последовательностей: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.C
    General information above from UniProt

    CD53 is a member of the transmembrane 4 superfamily, also called the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. Familial deficiency of CD53 gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. CD53 contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation.

    LFA-3 / CD58 Альтернативное название

    LFA3, [Cynomolgus]
    ag3,CD58,CD58 antigen,CD58 molecule,LFA3,LFA-3,lymphocyte function-associated antigen 3,RP5-1086K13.2,surface glycoprotein LFA-3, [human]

    LFA-3 / CD58 Связанные исследования

  • Rochelle JM. et al., 1993, Int Immunol. 5 (2): 209-16.
  • Virtaneva KI. et al., 1993, Immunogenetics. 37 (6): 461-5.
  • Horejsí V. et al., 1991, FEBS Lett. 288 (1-2): 1-4.
  • Внимание: все продукты «ПРЕДНАЗНАЧЕНЫ ИСКЛЮЧИТЕЛЬНО ДЛЯ ИССЛЕДОВАНИЙ И НЕ ПРЕДНАЗНАЧЕНЫ ДЛЯ ДИАГНОСТИКИ ИЛИ ТЕРАПЕВТИЧЕСКОГО ЛЕЧЕНИЯ».