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LCN2 / NGAL Антитело, Кроличьи поликлональные антитела, Antigen Affinity Purified

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Rat LCN2 Информация о продуктах-антителах
Иммуноген:Recombinant Rat LCN2 / NGAL protein (Catalog#80058-R08B)
Clone ID:
Тип Ig:Rabbit IgG
Концентрация:
Эндотоксин:
Состав:0.2 μm filtered solution in PBS with 5% trehalose
Подготовка:Produced in rabbits immunized with purified, recombinant Rat LCN2 / NGAL (rR LCN2 / NGAL; Catalog#80058-R08B; P30152; Met1-Asn198). LCN2 / NGAL specific IgG was purified by Rat LCN2 / NGAL affinity chromatography.
Rat LCN2 Руководство по использованию антител
Специфика:Rat LCN2 / NGAL
Заявление:ELISA, IHC-P

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Rat LCN2 / NGAL. The detection limit for Rat LCN2 / NGAL is approximately 0.00975 ng/well.

IHC-P: 0.1-2 μg/mL

Склад:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Rat LCN2 Antibody IHC Application Image
LCN2 / NGAL Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of rat LCN2 in rat epididymis with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other LCN2 Antibody Products
NGAL/LCN2/Lipocalin-2 Фон

Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells, like kidney tubular cells, may produce NGAL in response to various insults. This protein is released from injured tubular cells after various damaging stimuli, is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover, recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. NGAL, first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, oesophagus, brain) in humans. In thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation, proliferation, survival and morphogenesis.

Rat NGAL/LCN2/Lipocalin-2 Ссылки
  • Schmidt-Ott KM, et al. (2006) Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia. Curr Opin Nephrol Hypertens. 15(4): 442-9.
  • Bolignano D, et al. (2010) Neutrophil gelatinase-associated lipocalin (NGAL) in human neoplasias: a new protein enters the scene. Cancer Lett. 288(1): 10-6.
  • Soni SS, et al. (2010) NGAL: a biomarker of acute kidney injury and other systemic conditions. Int Urol Nephrol. 42(1): 141-50.
  • Bolignano D, et al. (2010) From kidney to cardiovascular diseases: NGAL as a biomarker beyond the confines of nephrology. Eur J Clin Invest. 40(3): 273-6.
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    Каталог: 80058-RP02-200
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    • LCN2 / NGAL Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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