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IL6 / Interleukin-6 Антитело, Кроличьи поликлональные антитела, Antigen Affinity Purified

  • IL6 / Interleukin-6 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • IL6 / Interleukin-6 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • IL6 / Interleukin-6 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Резус-фактор IL6 Информация о продуктах-антителах
Иммуноген:Recombinant Rhesus IL6 / Interleukin-6 protein (Catalog#90197-CNAE)
Clone ID:
Тип Ig:Rabbit IgG
Концентрация:
Эндотоксин:
Состав:0.2 μm filtered solution in PBS
Подготовка:Produced in rabbits immunized with purified, recombinant Rhesus IL6 / Interleukin-6 (Catalog#90197-CNAE; NP_001036198.2; Pro29-Met212). IL6 / Interleukin-6 specific IgG was purified by Rhesus IL6 / Interleukin-6 affinity chromatography.
Резус-фактор IL6 Antibody IHC Application Image
IL6 / Interleukin-6 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of cynomolgus IL6 in human liver with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
IL6 / Interleukin-6 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Щелкните, чтобы увеличить изображение]
Caption:
Immunochemical staining of cynomolgus IL6 in human spleen with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
IL6 / Interleukin-6 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Щелкните, чтобы увеличить изображение]
Caption:
Immunochemical staining of cynomolgus IL6 in human tonsil with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
Other IL6 Antibody Products

Anti-Histone H3 rabbit monoclonal antibody at 1:200 dilution

Lane A: NIH3T3 Whole Cell Lysate

Lane B: Hela Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.

Developed using the ECL technique.

Performed under reducing conditions.

Predicted band size:15 kDa

Observed band size:17 kDa

IL6/IL-6/Interleukin-6 Фон

Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Резус-фактор IL6/IL-6/Interleukin-6 Ссылки
  • Heinrich PC. et al. (2003). Principles of interleukin-6-type cytokine signalling and its regulation. Biochem J. 374: 1-20.
  • Rose-John S, et al. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 11(5): 613-24.
  • Dinh W, et al. (2009) Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders. Cardiovasc Diabetol. 8:58.
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    Каталог: 90197-RP02-50
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Внимание: все продукты «ПРЕДНАЗНАЧЕНЫ ИСКЛЮЧИТЕЛЬНО ДЛЯ ИССЛЕДОВАНИЙ И НЕ ПРЕДНАЗНАЧЕНЫ ДЛЯ ДИАГНОСТИКИ ИЛИ ТЕРАПЕВТИЧЕСКОГО ЛЕЧЕНИЯ».